TOC for Compendial Water Testing and Cleaning Validation; Comparison of Laboratory, At-Line, and Online Analysis

摘要

Total organic carbon (TOC) and conductivity testing are important quality control measures for ensuring water purity and equipment cleanliness and can be deployed to accommodate various sampling scenarios and efficiency needs. TOC and conductivity analysis help manufacturers achieve compliance to USP <643> and USP <645>, or with process control needs. While conductivity is traditionally measured with a meter and probe, advanced TOC technologies can also offer conductivity measurements simultaneously with TOC analysis. The three common deployments of TOC technology are laboratory, at-line, and online analysis. When choosing which strategy and deployment are best for a unique application, consider the following to ensure you get the most out of the technology.