Despite intensive efforts to collect essential tremor (ET) brains, the number of postmortem examinations remains limited, and the range of pathological changes associated with ET has not been fully catalogued [3]. We report an ET patient who had a pattern of pathological change not previously reported in ET or another neurological disease.The patient had childhood-onset, familial, kinetic arm tremor that progressively worsened during adulthood. She experienced difficulty eating and writing and developed head tremor. The clinical diagnosis was ET (see Supplementary online materials). She died at age 79 of myocardial infarction.
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