Five-year Long-term Outcomes of Stereotactic Body Radiation Therapy for Operable Versus Medically Inoperable Stage I Non-small-cell Lung Cancer: Analysis by Operability, Fractionation Regimen, Tumor Size, and Tumor Location

摘要

Stereotactic body radiation therapy is standard for inoperable stage I non-small-cell lung cancer and an emerging surgical alternative in operable patients. Limited long-term data exist according to operability. Analysis of 186 patients (204 lesions) demonstrates stereotactic body radiation therapy is well-tolerated with excellent local control (LC) (5-year LC, 93.7%). Inoperable patients achieved similar LC and cancer-specific survival but worse overall survival, likely owing to comorbidities.