Application of crystallization inhibitors to chiral separations. 2. Enhancing the chiral purity of mandelic acid by crystallization

摘要

In part 1 of this work, the successful design of additives for the selective inhibition of (R,S)-mandelic acid crystallization was described. Now, in part 2 of our study, we show how such additives may be used, together with the known ternary phase diagram, as the basis for a crystallization process that yields a chirally enriched product.