Exploring the effects of dietary lipid content and digestibility on lipophilic contaminants transfer from feed to milk in dairy cows: insights from a physiologically-based toxicokinetic modelling approach

摘要

Take home message A physiologically-based toxicokinetic (PBTK) model describes finely the fate of lipophilic contaminant in dairy cows. It allows handling of the complex interaction between cow nutrition and physiology, and contaminant properties whenassessing the risk of contaminant transfer from feed to milk.Livestock production faced several lipophilic pollutants (e.g. dioxins, polychlorinated biphenyls...) contamination incidents which compromise consumers' confidence and induce social distress for farmers. To face such hazards, integrative approaches should be developed for assessing the risk of on-farm contamination of ruminant milk and meat. Besides, the fate of lipophilic contaminant in ruminant should be understood and described finely by taking into account both animal physiology and nutrition, andcontaminant properties. The aims of this study were to set up a mechanistic physiologically-based toxicokinetic (PBTK) model describing the fate of lipophilic contaminant in dairy cows and further explore the effects of dietary lipid content and digestibility on the feed to milk transfer rate, depending on contaminant lipophilicity and metabolism clearance rate.