Evaluation of In Vitro Antiurolithiatic Potential of Bridelia retusa Spreng. Bark

摘要

Urolithisis is a very complex disease which is characterized by the formation of renal calculi in urinary track/kidney. Several physic chemical events like super saturation, nucleation, growth, aggregation and retention of dietary minerals of urine in the kidney leads to the formationof kidney stone; for this a essential need to develop a formulation which is made up of medicinal pant belong to the class of Pasanabheda plant according to ancient literature available in Ayurveda, which facilitate the repair mechanism in a natural way towards the organ. Brideliaretusa, is a well know plant of Western Ghats. Present study deals with the inhibitory effect of different fraction of methanol extract of Bridelia retusa. Nucleation of calcium oxalate crystals was estimated by the spectrophotometric assay and whereas crystal dissolution was determineby titrimetry/egg shell permeation method, hence the extract fractions exhibited inhibitory action in both of nucleation and aggregation assays to significant level.