Prematurity and neonatal outcome including congenital malformations after maternal malignancy within six months prior to or during pregnancy

Sabeti Rad Zahra; Friberg Britt; Henic Emir; Rylander Lars; St?hl Olof; K?llén Bengt; Lingman G?ran

摘要

Abstract <section xml:id="aogs13197-sec-0001"> <title type="main">Introduction >The proportion of women who postpone childbearing is increasing. As malignancy risk increases with age, pregnancy in connection with malignancy will become more common. </section> <section xml:id="aogs13197-sec-0002"> <title type="main">Material and methods >We compared infants born 1994–2011 to women with a malignancy within six months prior to the last menstrual period or during pregnancy with offspring of women without a previous malignancy. Five national registers were used. </section> <section xml:id="aogs13197-sec-0003"> <title type="main">Results >A total of 790 women with a malignancy diagnosis from six months prior to the last menstrual period up to delivery were identified. Their 802 infants were compared with 1?742?757 infants of women without a malignancy. A high rate of prematurity was found, especially when the malignancy was diagnosed during the second or third trimesters (33%). Most of these premature births were the result of induced delivery before 35?weeks (91%). The most remarkable finding is the observation that these premature infants had a significantly higher risk for neonatal morbidity than premature infants in the control group with an adjusted odds ratio of 2.67 (95% confidence interval; 1.86–3.84). We found a significantly increased risk of mainly relatively mild malformations among infants of women with a malignancy diagnosis within six months prior to the last menstrual period or during the first trimester with a risk ratio of 1.81 (95% confidence interval; 1.20–2.61). </section> <section xml:id="aogs13197-sec-0004"> <title type="main">Conclusions >A high incidence of prematurity, mostly due to induced delivery, was found, including an increased risk for neonatal morbidity among these infants. An increased risk for relatively mild malformations was also found. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：id =“aogs13197-abs-0001”> <标题类型=“main”>抽象</ title> < XML部分：ID =“AOGS13197-SEC-0001”> <标题类型=“main”>介绍</ title> >推迟生育的女性的比例正在增加。由于恶性风险随着年龄的增长而增加，怀孕与恶性肿瘤有关将变得更加常见。</ p> </ section> <section XML：ID =“AOGS13197-SEC-0002”> <标题类型=“main”>材料和方法</标题> >我们将1994 - 2011年的婴儿与在最后一次月经期前六个月内或在怀孕期间与未治疗的妇女后代怀孕期间的妇女。使用了五个国家寄存器。</ p> </ section> <section xml：id =“aogs13197-sec-0003”> <标题类型=“main”>结果</ title> >总共790名女性确定了从最后一次月经期前六个月到交付的恶性诊断。他们的802名婴儿与1？742？757婴儿没有恶性肿瘤。发现了高早期率，特别是当在第二个或第三个三个月或33％）期间诊断恶性肿瘤时。这些早产的大多数是在35？周（91％）之前诱导递送的结果。最卓越的发现是观察到这些早产儿新生儿发病风险明显更高，而不是对照组的早产儿，调整后的差率为2.67（95％置信区间; 1.86-3.84）。我们发现在最后一次月经期前六个月内或在前三个月的患有恶性诊断的患有恶性诊断的婴儿的显着增加的风险较大程度的患者，或者在第一个妊娠期为1.81（95％置信区间; 1.20-2.61）。 </ p> </ section> <section XML：ID =“AOGS13197-SEC-0004”> <标题类型=“main”>结论</标题> >高早期的发病率，主要是由于诱导递送，被发现，包括这些婴儿的新生儿发病的风险增加。还发现了相对温和的畸形的风险增加。</ p> </ section> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-17780/'>《Acta Obstetricia et Gynecologica Scandinavica: Official Publication of the Nordisk Forening for Obstetrik och Gynekologi》</a> <b style="margin: 0 2px;">|</b><span>2017年第11期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sabeti Rad Zahra&option=202" target="_blank" rel="nofollow">Sabeti Rad Zahra;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Friberg Britt&option=202" target="_blank" rel="nofollow">Friberg Britt;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Henic Emir&option=202" target="_blank" rel="nofollow">Henic Emir;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rylander Lars&option=202" target="_blank" rel="nofollow">Rylander Lars;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=St?hl Olof&option=202" target="_blank" rel="nofollow">St?hl Olof;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=K?llén Bengt&option=202" target="_blank" rel="nofollow">K?llén Bengt;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lingman G?ran&option=202" target="_blank" rel="nofollow">Lingman G?ran;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Center of Reproductive MedicineSk?ne University HospitalMalm? Sweden;</p> <p>Center of Reproductive MedicineSk?ne University HospitalMalm? Sweden;</p> <p>Center of Reproductive MedicineSk?ne University HospitalMalm? Sweden;</p> <p>Division of Occupational and Environmental MedicineLund UniversityLund Sweden;</p> <p>Department of OncologySk?ne University HospitalLund Sweden;</p> <p>Tornblad InstituteLund UniversityLund Sweden;</p> <p>Department of Obstetrics and GynecologyLund UniversityLund Sweden;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/197.html" title="妇产科学">妇产科学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Malignancy&option=203" rel="nofollow">Malignancy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=prematurity&option=203" rel="nofollow">prematurity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=induced delivery&option=203" rel="nofollow">induced delivery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neonatal morbidity&option=203" rel="nofollow">neonatal morbidity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=congenital malformations&option=203" rel="nofollow">congenital malformations;</a> </p> <div class="translation"> 机译：恶性;早产;诱导递送;新生儿发病率;先天性畸形; 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