Clinical characteristics and treatment outcome of adult acute lymphoblastic leukemia with t(4;11)(q21;q23) using a modified hyper-CVAD regimen.

摘要

The t(4;11)(q21;q23) chromosomal translocation resulting in the MLL-AF4 fusion gene represents the second most frequent structural cytogenetic abnormality of adult acute lymphoblastic leukemia (ALL), and is mainly associated with pro-B-cell ALL and a poor prognosis [1-6]. However, to date, most of the previously published studies were mainly aimed at pediatric ALL patients. The characteristics and outcomes of adult ALL patients with this chromosomal abnormality are still unclear, especially in patients who have received the modern intensified therapy. In light of this, we have summarized the clinical characteristics of 16 newly diagnosed ALL patients (age >=14 years) with t(4;11) chromosomal translocation and their outcomes after receiving our modified hyper-CVAD regimen between June 2003 and June 2007. The main objectives were: (1) to investigate clinical characteristics of Chinese adult ALL patients with t(4;11) and (2) to assess the efficiency of our modified hyper-CVAD regimen on the outcomes of this group of patients.