Specificity of interaction between receptor and G protein: use of antisense techniques to relate G-protein subunits to function

摘要

Hetertrimeric guanine nucleotide-binding proteins (G proteins) form a growing family of proteins mediating siganl transduction from the outside of the cell to the cytoplasm by interacting with receptor and effector proteins (for review see Refs. [1-8]. G proteins are composed of three subunits, a, b and y, of which at least 23 (including splice variants) different a forms (Ga), 6 different b forms (Gb) and 11 different y forms (Gy) exist.