Development and Validation of a Stability-Indicating HPLC Method for the Assay of Carvedilol in Pure and Tablet Dosage Forms

摘要

Background: Carvedilol (CD) is beta-blocker drug that is used in the treatment of hypertension, coronary diseases, etc. The official methods for the assay of CD in British Pharmacopoeia (BP) and United States Pharmacopeia (USP) include potentiometric titration and HPLC analysis, respectively. There are two different methods reported in the USP; one is for the pure CD and the other is for its tablet dosage forms. Both methods are time consuming, require stringent preparation and have specific requirements such as temperature.