Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats

Zeng Kuan; Li Mengzhu; Hu Jichang; Mahaman Yacoubou Abdoul Razak; Bao Jian; Huang Fang; Xia Yiyuan; Liu Xinghua; Wang Qun; Wang Jian-Zhi; Liu Rong; Wang Xiaochuan

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Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats

机译：Ginkgo Biloba Extract EGB761衰减高管高血症诱导的广告，如TAU高磷酸化和大鼠的认知障碍

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Background: Ginkgo biloba extract EGb761 has shown the neuroprotective effects on Alzheimer's disease (AD) through the protection against the A beta-induced neurotoxicity. However, it is not completedly clear whether EGb761 attenuates tau hyperphosphorylation, another of the most prominent mechanisms underlying the pathology of AD.

机译：背景：Ginkgo Biloba Extract EGB761通过防止β诱导的神经毒性，显示了对阿尔茨海默病（AD）的神经保护作用。然而，它没有完全清楚EGB761是否衰减TAU高磷酸化，另一个最突出的机制依赖于广告的病理学。

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来源
《Current Alzheimer research》 |2018年第1期|共11页
作者
Zeng Kuan; Li Mengzhu; Hu Jichang; Mahaman Yacoubou Abdoul Razak; Bao Jian; Huang Fang; Xia Yiyuan; Liu Xinghua; Wang Qun; Wang Jian-Zhi; Liu Rong; Wang Xiaochuan;
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作者单位

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

Huazhong Univ Sci &

Technol Minist Educ China Neurol Disorders Dept Pathophysiol Tongji Med Coll;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
Ginkgo biloba extract EGb761; Alzheimer's disease (AD); hyperhomocysteinemia (HHcy); tau hyperphosphorylation; cognitive impairment; oxidative damage;

机译：Ginkgo Biloba提取物EGB761;阿尔茨海默病（AD）;高管抑制症（HHCY）;TAU高磷酸化;认知障碍;氧化损伤;

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专利

1. Effects of Ginkgo biloba extract EGb761 on neural differentiation of stem cells offer new hope for neurological disease treatment [J] . Chao Ren, Yong-Qiang Ji, Hong Liu, 中国神经再生研究（英文版） . 2019,第007期
2. Extract of ginkgo biloba EGb761 inhibits cell apoptosis following spinal cord injury [J] . Jiejun Jiao, Jiannong Jiang, Bin Du, 中国神经再生研究：英文版 . 2010,第022期
3. Extract of ginkgo biloba EGb761 inhibits cell apoptosis following spinal cord injury [J] . Jiejun Jiao, Jiannong Jiang, Bin Du, 中国神经再生研究（英文版） . 2010,第022期
4. Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats [J] . Zeng Kuan, Li Mengzhu, Hu Jichang, Current Alzheimer research . 2018,第1期

机译：Ginkgo Biloba Extract EGB761衰减高管高血症诱导的广告，如TAU高磷酸化和大鼠的认知障碍
5. Administration of Ginkgo biloba Extract (EGb761) Alone and in Combination with FK506 Promotes Liver Regeneration in a Rat Model of Partial Hepatectomy [J] . Nahide Ekici Günay, Sabahattin Muhtaro?lu, Abdulkadir Bedirli Balkan Medical Journal . 2018,第2期

机译：银杏叶提取物（EGb761）的单独给药以及与FK506的组合可在部分肝切除大鼠模型中促进肝脏再生
6. Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. [J] . Takuma K, Hoshina Y, Arai S, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2007,第2期

机译：银杏叶提取物银杏叶提取物761减轻了卵巢切除大鼠的慢性束缚应激引起的海马神经元丧失和认知功能障碍。
7. Ginkgo biloba extract (EGb761) protects against adriamycin-induced cardiotoxicity without interfereing with its antitumor activity [C] . Ding Qinxue, Liu Gengtao Proceedings of '97 international seminar on ginkgo . 1997

机译：银杏叶提取物（EGb761）可防止阿霉素引起的心脏毒性，而不会干扰其抗肿瘤活性
8. Neuroprotective Mechanisms of Ginkgo Biloba extract (EGb761) in Alzheimer's Disease. [D] . Shi, Chun. 2010

机译：银杏叶提取物（EGb761）在阿尔茨海默氏病中的神经保护机制。
9. Administration of Ginkgo biloba Extract (EGb761) Alone and in Combination with FK506 Promotes Liver Regeneration in a Rat Model of Partial Hepatectomy [O] . Nahide Ekici Günay, Sabahattin Muhtaroğlu, Abdulkadir Bedirli 2018

机译：银杏叶提取物（EGb761）的单独给药以及与FK506的组合可在部分肝切除的大鼠模型中促进肝脏再生
10. Hyperbaric Oxygen and Ginkgo Biloba Extract Ameliorate Cognitive and Memory Impairment via Nuclear Factor Kappa-B Pathway in Rat Model of Alzheimer′s Disease [O] . Li-Da Zhang, Li Ma, Li Zhang, 2015

机译：高压氧和银杏叶提取物通过核因子Kappa-B途径改善阿尔茨海默病大鼠模型的认知和记忆障碍

Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats

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