Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells

摘要

Intestinal homeostasis relies on the reciprocal crosstalk between enteric neurons and immune cells, which together form neuroimmune units that occupy distinct anatomical niches within the gut. Here wewill review the recent advancesin our understanding of neuro-immune crosstalk within the gut, with focus on macrophages, mast cells and innate lymphoid cells. In particular, we will discuss the role of neuron-immune cell crosstalk in homeostasis, and how aberrant communication may underlie disease in the gastro-intestinal tract.