Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk

摘要

Purpose of the ReviewTo summarize current knowledge on interactions between genetic variants and lifestyle factors (GxL) associated with the development of coronary artery disease (CAD) and prioritize future research.Recent FindingsGenetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD.SummaryFirst, we describe genetic and lifestyle factors associated with CAD and then focus on GxL interactions. The majority of GxL interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of GxL interactions in the development of CAD. Further GxL interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.