P-42 A case of early enucleation of supernumerary teeth in a patient with cleidocranial dysplasia

摘要

Cleidocranial dysplasia (CCD) is an autosomal dominant disease that is caused by mutations in the RUNX2 (CBFA1) gene. CCD is characterized by clavicular hypoplasia as well as delayed formation of cranial sutures. Intraoral problems include impacted supernumerary teeth and delayed eruption of permanent dentition. Distribution and frequency of appearance of both impacted supernumerary teeth and delayed eruption of permanent teeth was investigated in 16 patients with CCD (11 men and five women) in our orthodontic clinic and reported at the 54th annual meeting of the Japanese Teratology Society. Reports discussing the timing of appearance and the position of supernumerary teeth are rare, because there are few opportunities to examine pediatric patients with CCD. We report a patient with CCD who was observed from childhood and who underwent enucleation of the supernumerary tooth germs in the early stage. Case: An 8-year-old girl visited our orthodontic clinic with a chief complaint of anterior crossbite. CT imaging revealed supernumerary tooth germs of four teeth in the maxilla and seven teeth in the mandible at 9 years of age. All supernumerary teeth were enucleated under general anesthesia at 10 years of age. The supernumerary teeth were located in the anterior and premolar regions of the maxilla and mandible, all on the lingual side. It is suggested that early enucleation of the supernumerary tooth germ may promote eruption of the permanent teeth.