Biodegradable Poly(Acetonide Gluconic Acid) for Controlled Drug Delivery

摘要

We report here on the synthesis, characterization, degradation, and drug release of acetal-protected gluconic acid-based poly(alpha-hydroxy ester). This polyester was synthesized by ring-opening polymerization of O-carboxyan-hydride of acetal-protected gluconic acid. The polymer OH undergoes hydrolytic degradation under mild acidic media, whereas minimal degradation takes place under physiological pH. Under acidic conditions, the acetal-protecting groups are hydrolyzed, resulting in a water-soluble polyester with saccharide side chains that erodes from the surface, leaving the bulk of the polymer matrix intact. At pH 3.5, zero-order kinetics was maintained for 50 days accounting for similar to 75% drug release. These biodegradable, pH-responsive, sustained zero-order release kinetics of the polymer have application as drug carriers for oral drug delivery or medical implants or also for nonmedical applications.