HIV patients, healthy aging and transplant recipients can reveal the hidden footprints of CMV

摘要

Cytomegalovirus (CMV) is a beta-herpesvirus. Latent infections are common in all populations. However age associated increases in levels of CMV-reactive antibody are testament to repeated reactivations and periods of viral replication. CMV has been associated with several diseases of aging, including vasculopathy and neurocognitive impairment. These conditions occur at a younger age in persons with particularly high burdens of CMV - transplant recipients and people living with HIV. Here we define the "clinical footprints" as immunopathologies triggered by CMV that develop over many years.