Herbal Remedies: Throwing Off Phenotype Prediction-A Culprit for Pharmacogenomic-Guided Drug Therapy and Drug Safety

摘要

Pharmacotherapy aims to provide cost-effective relief of disease symptoms for improved patient quality of life. However, most drugs are not 100% effective due to several factors, including genetic variability in drug targets and drug-metabolizing enzymes. 1 There are efforts to address these challenges focusing on evaluating gene-drug-response associations that can be used to stratify patient responses or phenotypes for pharmacotherapy.