The Complementary Role of Ga-68-DOTATATE PET/CT in Neuroblastoma

摘要

A girl diagnosed with neuroblastoma at 33 months underwent I-123-MIBG scan after surgery and chemoradiotherapy. Although MIBG scan showed complete response, the bone marrow biopsy showed refractory disease. Therefore, she underwent Ga-68-DOTATATE PET/CT, which revealed bone marrow involvement and Ga-68-DOTATATE-avid brain metastasis. Rare physiological pineal gland uptake was also depicted. Ga-68-DOTATATE PET/CT showed active progressive disease earlier, before it was detectable with MIBG scan. For patients with MIBG-negative relapsed/refractory disease, Ga-68-DOTATATE may have an important role in restaging, detecting unsuspected metastasis, therapy planning.