Safety, Pharmacokinetics, and Pharmacodynamics of ME-401, an Oral, Potent, and Selective Inhibitor of Phosphatidylinositol 3-Kinase P110 delta, Following Single Ascending Dose Administration to Healthy Volunteers

摘要

Purpose: ME-401 is a novel selective inhibitor of phosphatidylinositol 3 kinase p110 delta, an enzyme often found overexpressed and overactive in B-cell malignancies. The current study was performed to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending oral doses of ME-401 in healthy volunteers.