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首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia
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A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia

机译：CPI-613与高剂量的患有急性髓鞘白血病的高剂量红细胞和尿催化剂组合研究CPI-613的阶段

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Purpose: CPI-613, a lipoate analogue that inhibits pyruvate dehydrogenase (PDH) and alpha-ketogluterate dehydrogenase (KGDH), has activity in patients with myeloid malignancies. This study explored the role of mitochondrial metabolism in chemotherapy response and determined the MTD, efficacy, and safety of CPI-613 combined with high-dose cytarabine and mitoxantrone in patients with relapsed or refractory acute myeloid leukemia.
机译：目的：CPI-613，一种抑制丙酮酸脱氢酶（PDH）和α-酮戊酰脱氢酶（KGDH）的脂质酸盐类似物，具有骨髓恶性肿瘤患者的活性。 本研究探讨了线粒体代谢在化疗反应中的作用，并确定了CPI-613的MTD，疗效和安全性与高剂量的急性髓白血病患者中的高剂量红霉菌和丝兰蒽醌联合。

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    Pardee Timothy S.; Anderson Rebecca G.; Pladna Kristin M.; Isom Scott; Ghiraldeli Lais P.; Miller Lance D.; Chou Jeff W.; Jin Guangxu; Zhang Wei; Ellis Leslie R.; Berenzon Dmitriy; Howard Dianna S.; Hurd David D.; Manuel Megan; Dralle Sarah; Lyerly Susan; Powell Bayard L.;

  • 作者单位

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Publ Hlth Sci Dept Biostat Sci Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Dept Canc Biol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Dept Canc Biol Winston Salem NC USA;

    Wake Forest Publ Hlth Sci Dept Biostat Sci Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Biostat Core Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Dept Canc Biol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

    Wake Forest Baptist Hlth Ctr Comprehens Canc Sect Hematol &

    Oncol Winston Salem NC USA;

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