Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study

Burke Michael J.; Kostadinov Rumen; Sposto Richard; Gore Lia; Kelley Shannon M.; Rabik Cara; Trepel Jane B.; Lee Min-Jung; Yuno Akira; Lee Seonju; Bhojwani Deepa; Jeha Sima; Chang Bill H.; Sulis Maria Luisa; Hermiston Michelle L.; Gaynon Paul; Van Huynh; Verma Anupam; Gardner Rebecca; Heym Kenneth M.; Dennis Robyn M.; Ziegler David S.; Laetsch Theodore W.; Oesterheld Javier E.; Dubois Steven G.; Pollard Jessica A.; Glade-Bender Julia; Cooper Todd M.; Kaplan Joel A.; Farooqi Midhat S.; Yoo Byunggil; Guest Erin; Wayne Alan S.; Brown Patrick A.

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study

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Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study

机译：Defitabine和Vorinostat在复发小儿急性淋巴细胞白血病中的化疗：TACL试点研究

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Purpose: Treatment failure from drug resistance is the primary reason for relapse in acute lymphoblastic leukemia (ALL). Improving outcomes by targeting mechanisms of drug resistance is a potential solution.

机译：目的：耐药性的治疗失败是急性淋巴细胞白血病（全部）中复发的主要原因。通过靶向耐药机制来改善结果是潜在的解决方案。

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来源
《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2020年第10期|共11页
作者
Burke Michael J.; Kostadinov Rumen; Sposto Richard; Gore Lia; Kelley Shannon M.; Rabik Cara; Trepel Jane B.; Lee Min-Jung; Yuno Akira; Lee Seonju; Bhojwani Deepa; Jeha Sima; Chang Bill H.; Sulis Maria Luisa; Hermiston Michelle L.; Gaynon Paul; Van Huynh; Verma Anupam; Gardner Rebecca; Heym Kenneth M.; Dennis Robyn M.; Ziegler David S.; Laetsch Theodore W.; Oesterheld Javier E.; Dubois Steven G.; Pollard Jessica A.; Glade-Bender Julia; Cooper Todd M.; Kaplan Joel A.; Farooqi Midhat S.; Yoo Byunggil; Guest Erin; Wayne Alan S.; Brown Patrick A.;
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作者单位

Med Coll Wisconsin Div Pediat Hematol Oncol Milwaukee WI 53226 USA;

Johns Hopkins Univ Div Pediat Oncol Baltimore MD USA;

Univ Southern Calif Childrens Hosp Los Angeles Childrens Ctr Canc &

Blood Dis USC Norris;

Univ Colorado Childrens Hosp Colorado Sch Med Aurora CO USA;

Johns Hopkins Univ Div Pediat Oncol Baltimore MD USA;

Johns Hopkins Univ Div Pediat Oncol Baltimore MD USA;

NCI NIH Bethesda MD 20892 USA;

NCI NIH Bethesda MD 20892 USA;

NCI NIH Bethesda MD 20892 USA;

NCI NIH Bethesda MD 20892 USA;

Univ Southern Calif Childrens Hosp Los Angeles Childrens Ctr Canc &

Blood Dis USC Norris;

St Jude Childrens Res Hosp 332 N Lauderdale St Memphis TN 38105 USA;

Oregon Hlth &

Sci Univ Dept Pediat 3181 Sw Sam Jackson Pk Rd Portland OR 97201 USA;

Mem Sloan Kettering Canc Ctr Dept Pediat 1275 York Ave New York NY 10021 USA;

UCSF Med Ctr Mission Bay Dept Pediat San Francisco CA USA;

Johns Hopkins Univ Div Pediat Oncol Baltimore MD USA;

Childrens Hosp Orange Cty Dept Pediat Orange CA 92668 USA;

Univ Utah Primary Childrens Hosp Dept Pediat Salt Lake City UT USA;

Seattle Childrens Hosp Dept Pediat Washington DC USA;

Cook Childrens Med Ctr Dept Pediat Ft Worth TX USA;

Nationwide Childrens Hosp Dept Pediat Columbus OH USA;

Sydney Childrens Hosp Kids Canc Ctr Randwick NSW Australia;

UT Southwestern Harold C Simmons Comprehens Canc Ctr Dept Pediat Dallas TX USA;

Carolinas Med Ctr Levine Canc Inst Dept Pediat Charlotte NC 28203 USA;

Boston Childrens Canc &

Blood Disorders Ctr Dept Pediat Dana Farber Boston MA USA;

Boston Childrens Canc &

Blood Disorders Ctr Dept Pediat Dana Farber Boston MA USA;

Mem Sloan Kettering Canc Ctr Dept Pediat 1275 York Ave New York NY 10021 USA;

Seattle Childrens Hosp Dept Pediat Washington DC USA;

Carolinas Med Ctr Levine Canc Inst Dept Pediat Charlotte NC 28203 USA;

Childrens Mercy Hosp Ctr Pediat Genom Med Kansas City MO 64108 USA;

Childrens Mercy Hosp Ctr Pediat Genom Med Kansas City MO 64108 USA;

Childrens Mercy Hosp Ctr Pediat Genom Med Kansas City MO 64108 USA;

Johns Hopkins Univ Div Pediat Oncol Baltimore MD USA;

Johns Hopkins Univ Div Pediat Oncol Baltimore MD USA;

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正文语种 eng
中图分类肿瘤学;
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专利

1. Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study [J] . Burke Michael J., Kostadinov Rumen, Sposto Richard, Clinical cancer research: an official journal of the American Association for Cancer Research . 2020,第10期

机译：Defitabine和Vorinostat在复发小儿急性淋巴细胞白血病中的化疗：TACL试点研究
2. A therapeutic trial of decitabine and vorinostat in combination with chemotherapy for relapsed/refractory acute lymphoblastic leukemia [J] . BurkeM.J., LambaJ.K., PoundsS., American Journal of Hematology . 2014,第9期

机译：结合复发/难治性急性淋巴细胞白血病的化疗结合切宾单和Vorinostat的治疗试验
3. A phase i study of EZN-3042, a novel survivin messenger ribonucleic acid (mRNA) antagonist, administered in combination with chemotherapy in children with relapsed acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium [J] . RaetzE.A., MorrisonD., Romanos-SirakisE., Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology . 2014,第6期

机译：EZN-3042的一项i期研究，一种新型的survivin信使核糖核酸（mRNA）拮抗剂，与化疗联合用于儿童复发性急性淋巴细胞白血病（ALL）：儿童白血病和淋巴瘤（TACL）的治疗进展报告财团
4. Arsenic Salvage Is Superior to Chemotherapy and Bone Marrow Transplantation for Relapsed Acute promyelocytic Leukemia: Ten Years of Experience from Hong Kong [C] . W.Y. Au, R. Liang, A.K.W. Lie, European Haematology Association . 2002

机译：砷救生优于化疗和骨髓移植复发急性突出细胞细胞白血病：来自香港的十年经验
5. Somatic Mutation Detection in Leukemia-Derived Circulating DNA: Utility in Monitoring Clonal Dynamics and Disease Response in Pediatric Acute Lymphoblastic Leukemia [D] . Youssef, Sarah Hisham Abdelaziz. 2018

机译：白血病衍生循环DNA中的体细胞突变检测：小儿急性淋巴细胞白血病监测克隆动力学和疾病反应的效用
6. A Therapeutic Trial of Decitabine and Vorinostat in Combination with Chemotherapy for Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) [O] . Michael J. Burke, Jatinder K Lamba, Stanley Pounds, -1

机译：地西他滨和伏立诺他联合化学疗法治疗复发/难治性急性淋巴细胞白血病（ALL）的治疗性试验。
7. Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia (TACL) consortium [O] . Yoav Messinger, Paul Gaynon, Elizabeth Raetz, 2010

机译：Ⅰ期博尔特佐米与复发儿童急性淋巴细胞白血病儿童联合化疗（全部）：儿童白血病（TACL）联盟的治疗进展报告

Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study

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