Phase II Study of Alemtuzumab (CAMPATH-1) in Patients with HTLV-1-Associated Adult T-cell Leukemia/lymphoma

Sharma Kamal; Janik John E.; OMahony Deirdre; Stewart Donn; Pittaluga Stefania; Stetler-Stevenson Maryalice; Jaffe Elaine S.; Raffeld Mark; Fleisher Thomas A.; Lee Cathryn C.; Steinberg Seth M.; Waldmann Thomas A.; Morris John C.

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Phase II Study of Alemtuzumab (CAMPATH-1) in Patients with HTLV-1-Associated Adult T-cell Leukemia/lymphoma

机译：HTLV-1相关成人T细胞白血病/淋巴瘤患者Alemtuzumab（Campath-1）的II期研究

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Purpose: Therapeutic regimens for adult T-cell leukemia/lymphoma (ATL) are limited with unsatisfactory results, thereby warranting development of novel therapies. This study investigated antitumor activity and toxicity of alemtuzumab with regard to response, duration of response, progression-free survival, and overall survival in patients with human T-cell lymphotropic virus-1 (HTLV-1)-associated ATL.

机译：目的：成人T细胞白血病/淋巴瘤（ATL）的治疗方案受到不令人满意的结果，从而有权开发新的疗法。本研究研究了Alemtuzumab的抗肿瘤活性和毒性，关于响应，反应的持续时间，人类T细胞淋巴卵雌性病毒-1（HTLV-1） - 分配的ATL患者的患者的整体存活。

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第1期|共8页
作者
Sharma Kamal; Janik John E.; OMahony Deirdre; Stewart Donn; Pittaluga Stefania; Stetler-Stevenson Maryalice; Jaffe Elaine S.; Raffeld Mark; Fleisher Thomas A.; Lee Cathryn C.; Steinberg Seth M.; Waldmann Thomas A.; Morris John C.;
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作者单位

NCI Ctr Canc Res Lymphoid Malignancies Branch Bethesda MD USA;

NCI Ctr Canc Res Lymphoid Malignancies Branch Bethesda MD USA;

NCI Ctr Canc Res Lymphoid Malignancies Branch Bethesda MD USA;

NCI Ctr Canc Res Lymphoid Malignancies Branch Bethesda MD USA;

NCI Ctr Canc Res Lab Pathol Bethesda MD USA;

NCI Ctr Canc Res Lab Pathol Bethesda MD USA;

NCI Ctr Canc Res Lab Pathol Bethesda MD USA;

NCI Ctr Canc Res Lab Pathol Bethesda MD USA;

NIH Clin Pathol Dept Mark O Hatfield Clin Res Ctr Bethesda MD USA;

NCI Ctr Canc Res Lymphoid Malignancies Branch Bethesda MD USA;

NCI Biostat &

Data Management Sect Off Clin Director Ctr Canc Res Bethesda MD USA;

NCI Ctr Canc Res Lymphoid Malignancies Branch Bethesda MD USA;

NCI Ctr Canc Res Lymphoid Malignancies Branch Bethesda MD USA;

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正文语种 eng
中图分类肿瘤学;
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专利

1. Phase II Study of Alemtuzumab (CAMPATH-1) in Patients with HTLV-1-Associated Adult T-cell Leukemia/lymphoma [J] . Sharma Kamal, Janik John E., OMahony Deirdre, Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第1期

机译：HTLV-1相关成人T细胞白血病/淋巴瘤患者Alemtuzumab（Campath-1）的II期研究
2. Outcome of patients with HTLV-1-associated adult T-cell leukemia/lymphoma after SCT: a retrospective study by the EBMT LWP. [J] . A Bazarbachi, K Cwynarski, A Boumendil, Bone marrow transplantation . 2014,第10期

机译：SCT后HTLV-1相关成人T细胞白血病/淋巴瘤患者的结果：EBMT LWP的回顾性研究。
3. THP-COP regimen for the treatment of peripheral T-cell lymphoma and adult T-cell leukemia/lymphoma: a multicenter phase II study. [J] . Takamatsu Y, Suzumiya J, Utsunomiya A, European Journal of Haematology . 2010,第5期

机译：THP-COP方案治疗周围性T细胞淋巴瘤和成人T细胞白血病/淋巴瘤：一项多中心II期研究。
4. ADULT T-CELL LYMPHOMA/LEUKEMIA - MYSTERIOUS DISEASE [C] . KAZUHIKO NATORI, DAISUKE NAGASE, SUSUMU ISHIHARA, International Conference on Cellular and Molecular Biology, Biophysics and Bioengineering . 2013

机译：成人T细胞淋巴瘤/白血病 - 神秘疾病
5. Molecular characterization of HTLV-I integration sites in patients with adult T-cell leukemia/lymphoma. [D] . Kemper, Robert Russell, Jr. 1994

机译：成人T细胞白血病/淋巴瘤患者HTLV-1整合位点的分子特征。
6. Phase II study of alemtuzumab (CAMPATH-1®) in patients with HTLV-1-associated adult T-cell leukemia/lymphoma [O] . Kamal Sharma, John E. Janik, Deirdre O’Mahony, -1

机译：Alemtuzumab（CAMPATH-1®）在HTLV-1相关的成人T细胞白血病/淋巴瘤患者中进行的II期研究
7. Phase II Study of Alemtuzumab (CAMPATH-1) in Patients with HTLV-1–Associated Adult T-cell Leukemia/lymphoma [O] . Kamal Sharma, John E. Janik, Deirdre OMahony, 2016

机译：HTLV-1相关成人T细胞白血病/淋巴瘤患者Alemtuzumab（Campath-1）的II期研究

Phase II Study of Alemtuzumab (CAMPATH-1) in Patients with HTLV-1-Associated Adult T-cell Leukemia/lymphoma

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