A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors

Atrafi Florence; Groen Harry J. M.; Byers Lauren A.; Garralda Elena; Lolkema Martijn P.; Sangha Randeep S.; Viteri Santiago; Chae Young Kwang; Camidge D. Ross; Gabrail Nashat Y.; Hu Beibei; Tian Tian; Nuthalapati Silpa; Hoening Elizabeth; He Lei; Komarnitsky Philip; Calles Antonio

首页> 外文期刊>Clinical cancer research: an official journal of the American Association for Cancer Research >A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors

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A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors

机译：在广泛阶段小细胞肺癌和其他实体肿瘤患者中，尿基石与卡铂和依托磷脂联合Carboplatin和依托泊苷的一期 - 升级研究

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Purpose: This study examined safety, pharmacokinetics, and efficacy of veliparib, a PARP inhibitor, combined with carboplatin and etoposide in patients with extensive-stage (ED) small cell lung cancer (SCLC) and other solid tumors.

机译：目的：本研究检测了Veliparib，PARP抑制剂的安全性，药代动力学和疗效，与广泛的阶段（ED）小细胞肺癌（SCLC）和其他实体瘤的患者中的卡铂抑制剂和依托泊苷。

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《Clinical cancer research: an official journal of the American Association for Cancer Research 》 |2019年第2期| 共10页
作者
Atrafi Florence; Groen Harry J. M.; Byers Lauren A.; Garralda Elena; Lolkema Martijn P.; Sangha Randeep S.; Viteri Santiago; Chae Young Kwang; Camidge D. Ross; Gabrail Nashat Y.; Hu Beibei; Tian Tian; Nuthalapati Silpa; Hoening Elizabeth; He Lei; Komarnitsky Philip; Calles Antonio;
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作者单位

Erasmus MC Rotterdam Netherlands;

Univ Groningen Groningen Netherlands;

Univ Texas MD Anderson Canc Ctr Houston TX 77030 USA;

START Madrid Ctr Integral Oncol Clara Campal Madrid Spain;

Erasmus MC Rotterdam Netherlands;

Cross Canc Inst Edmonton AB Canada;

Dexeus Univ Hosp Dr Rosell Oncol Inst QuironSalud Grp Barcelona Spain;

Northwestern Univ Feinberg Sch Med Chicago IL 60611 USA;

Univ Colorado Canc Ctr Aurora CO USA;

Gabrail Canc Ctr Canton OH USA;

AbbVie Inc N Chicago IL USA;

AbbVie Inc N Chicago IL USA;

AbbVie Inc N Chicago IL USA;

AbbVie Inc N Chicago IL USA;

AbbVie Inc N Chicago IL USA;

AbbVie Inc N Chicago IL USA;

START Madrid Ctr Integral Oncol Clara Campal Madrid Spain;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学 ;
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1. A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors [J] . Atrafi Florence, Groen Harry J. M., Byers Lauren A., Clinical cancer research: an official journal of the American Association for Cancer Research . 2019 ,第2期

机译：在广泛阶段小细胞肺癌和其他实体肿瘤患者中，尿基石与卡铂和依托磷脂联合Carboplatin和依托泊苷的一期 - 升级研究
2. A phase ib dose-escalation study of everolimus combined with cisplatin and etoposide as first-line therapy in patients with extensive-stage small-cell lung cancer [J] . BesseB., HeistR.S., PapadmitrakopoulouV.A., Annals of oncology: official journal of the European Society for Medical Oncology . 2014 ,第2期

机译：Evenolimus的IB剂量升级研究与顺铂和依托泊苷相结合，作为广泛阶段小细胞肺癌患者的一线治疗
3. Biomarker analysis in a phase III study of pemetrexed-carboplatin versus etoposide-carboplatin in chemonaive patients with extensive-stage small-cell lung cancer [J] . SmitE.F., SocinskiM.A., MullaneyB.P., Annals of oncology: official journal of the European Society for Medical Oncology . 2012 ,第7期

机译：培美曲塞-卡铂与依托泊苷-卡铂在化疗合并广泛期小细胞肺癌患者中的III期研究中的生物标志物分析
4. Lung Tumor Segmentation using Coupling-Net with Shape-focused Prior on Chest CT Images of Non-small Cell Lung Cancer Patients [C] . Sohyun Byun, Julip Jung, Helen Hong, Medical Imaging Conference . 2020

机译：非小细胞肺癌患者胸部CT图像上的形状聚焦先验耦合网络联合肺肿瘤分割
5. Safety and Efficacy of the Immunomodulatory Drug (IMiD) Lenalidomide in Patients with Lymphoma: Development of RU051417I - Phase I/II Open-Label Study of R-ICE (Rituximab-Ifosfamide-Carboplatin-Etoposide) with Lenalidomide [R2-ICE] in Patients with First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL). [D] . Kasi, Pashtoon Murtaza. 2018

机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
6. A Phase I study of AT-101 with Cisplatin and Etoposide in patients with advanced solid tumors with an Expanded Cohort in Extensive-Stage Small Cell Lung Cancer [O] . William R. Schelman, Tabraiz A. Mohammed, Anne M. Traynor, -1

机译：AT-101联合顺铂和依托泊苷治疗广泛期小细胞肺癌晚期实体瘤患者
7. 50P A phase Ib study of CC-90011, a potent, reversible, oral LSD1 inhibitor, plus etoposide and cisplatin (EP) or carboplatin (EC) in patients (Pts) with first-line (1L) extensive-stage (ES) small cell lung cancer (SCLC): Updated results [O] . S. Ponce Aix, O. Juan-Vidal, E. Carcereny, 2021

机译：50p CC-90011的IA相IB研究，患者（PTS）中的含量，可逆，口服LSD1抑制剂，依托皂苷和顺铂（EP）或卡铂（EC），具有一线（1L）广泛阶段（ES）小细胞肺癌（SCLC）：更新结果

A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors

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