Sample-dependent diagnostic accuracy of prostaglandin D synthase in cerebrospinal fluid leak

摘要

Background: Prostaglandin D2 synthase, commonly known as beta-trace protein (beta TP), is an excellent biomarker for the assessment of cerebrospinal fluid (CSF) leaks. Despite being widely used, the limits for the diagnostic values of beta TP are not well established to date, and currently suggested cut-off values in literature range from 0.25 to 6.0 mg/L. Sample-specific and more accurate thresholds are a current need.