Effects of Prostaglandins E2 and F2 alpha on the Carotid Arterial Blood Flow, Cerebrospinal Fluid Pressure and Intraocular Pressure in Dogs

摘要

The effects of prostaglandins (PGE2) and (PGF2 alpha) on carotid arterial blood flow, intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) were studied in anesthetized dogs. It was found that an i.v. infusion of PGE2 decreases systemic arterial pressure, and increases heart rate, carotid arterial blood flow, IOP and CSFP. During the period of infusion, however, after an initial increase, carotid arterial pressure gradually decreases to control levels. In contrast, an i.v. infusion of PGF2 alpha decreases heart rate, carotid arterial blood flow, IOP and CSFP, as mean systemic arterial pressure remains essentially unchanged. This study suggests that the changes in IOP induced by PGE2 or PGF2 alpha are not only due to their direct effect on the eye but also due to their effect on carotid arterial blood flow. In contrast, the changes in the CSFP are most likely due only to the effects of PGE2 and PGF2 alpha on carotid arterial blood flow. (Author)