New data on catecholaminergic polymorphic ventricular tachycardia in Japan - From the bench to the bedside

摘要

In the 1880 s, Sydney Ringer confirmed that calcium (Ca2+) was an essential second messenger for the heart. It is also a key link between data collected from laboratories (bench) and therapeutic application (bedside) for patients with diseased hearts. Abnormal Ca2+ handling by the sarcoplasmic reticulum (SR), the storage organelle in cardiomyocytes, has been shown to play a crucial role in the pathogenesis of heart failure and lethal arrhythmia.