Evidence for the involvement of TNF-alpha, IL-1 beta and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents

Sandes Silvia M. S.; Heimfarth Luana; Brito Renan G.; Santos Priscila L.; Gouveia Daniele N.; Carvalho Alexandra M. S.; Quintans Jullyana S. S.; da Silva-Junior Edeildo F.; de Aquino Thiago M.; Franca Paulo H. B.; de Araujo-Junior Joao X.; Albuquerque-Junior Ricardo L. C.; Zengin Gokhan; Schmitt Martine; Bourguignon Jean-Jacques; Quintans-Junior Lucindo J.

首页> 外文期刊>Chemico-biological interactions >Evidence for the involvement of TNF-alpha, IL-1 beta and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents

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Evidence for the involvement of TNF-alpha, IL-1 beta and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents

机译：TNF-α，IL-1β和IL-10参与的证据在吲哚-3-胍基腙盐酸吲哚-3-胍基腙的抗炎症和抗炎作用中，芳族氨基胍，啮齿动物

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摘要

Background: Indole-3-guanylhydrazone hydrochloride (LQM01) is a new derivative of aminoguanidine hydrochloride, an aromatic aminoguanidine.

机译：背景：吲哚-3-胍基腙盐酸盐（LQM01）是盐酸氨基胍的新衍生物，芳族氨基胍。

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来源
《Chemico-biological interactions》 |2018年第2018期|共10页
作者
Sandes Silvia M. S.; Heimfarth Luana; Brito Renan G.; Santos Priscila L.; Gouveia Daniele N.; Carvalho Alexandra M. S.; Quintans Jullyana S. S.; da Silva-Junior Edeildo F.; de Aquino Thiago M.; Franca Paulo H. B.; de Araujo-Junior Joao X.; Albuquerque-Junior Ricardo L. C.; Zengin Gokhan; Schmitt Martine; Bourguignon Jean-Jacques; Quintans-Junior Lucindo J.;
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作者单位

Univ Fed Sergipe Grad Program Hlth Sci Lab Neurosci &

Pharmacol Assay LANEF Sao Cristovao;

Univ Fed Sergipe Grad Program Hlth Sci Lab Neurosci &

Pharmacol Assay LANEF Sao Cristovao;

Univ Fed Sergipe Grad Program Hlth Sci Lab Neurosci &

Pharmacol Assay LANEF Sao Cristovao;

Univ Fed Sergipe Grad Program Hlth Sci Lab Neurosci &

Pharmacol Assay LANEF Sao Cristovao;

Univ Fed Sergipe Grad Program Hlth Sci Lab Neurosci &

Pharmacol Assay LANEF Sao Cristovao;

Univ Fed Sergipe Grad Program Hlth Sci Lab Neurosci &

Pharmacol Assay LANEF Sao Cristovao;

Univ Fed Sergipe Grad Program Hlth Sci Lab Neurosci &

Pharmacol Assay LANEF Sao Cristovao;

Univ Fed Alagoas Chem &

Biotechnol Inst Maceio Alagoas Brazil;

Univ Fed Alagoas Chem &

Biotechnol Inst Maceio Alagoas Brazil;

Univ Fed Alagoas Lab Med Chem Nursing &

Pharm Sch Maceio Alagoas Brazil;

Univ Fed Alagoas Lab Med Chem Nursing &

Pharm Sch Maceio Alagoas Brazil;

Univ Tiradentes Technol &

Res Inst ITP Aracaju Sergipe Brazil;

Selcuk Univ Sci Fac Dept Biol Campus Konya Turkey;

Univ Strasbourg Lab Excellence Medalis Lab Innovat Therapeut Fac Pharm Lab Excellence Medalis;

Univ Strasbourg Lab Excellence Medalis Lab Innovat Therapeut Fac Pharm Lab Excellence Medalis;

Univ Fed Sergipe Grad Program Hlth Sci Lab Neurosci &

Pharmacol Assay LANEF Sao Cristovao;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Guanidine; Indole; Inflammation; Pain; c-Fos; Antioxidant;

机译：胍;吲哚;炎症;疼痛;C-FOS;抗氧化剂;

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1. Evidence for the involvement of TNF-alpha, IL-1 beta and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents [J] . Sandes Silvia M. S., Heimfarth Luana, Brito Renan G., Chemico-biological interactions . 2018,第期

机译：TNF-α，IL-1β和IL-10参与的证据在吲哚-3-胍基腙盐酸吲哚-3-胍基腙的抗炎症和抗炎作用中，芳族氨基胍，啮齿动物
2. Evidence for the involvement of TNF-alpha and IL-1 beta in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-alpha-bisabolol, its main compound, in mice [J] . Barreto Rosana S. S., Quintans Jullyana S. S., Amarante Ruthy K. L., Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2016,第Null期

机译：TNF-α和IL-1β参与的证据表明Stachys Lavandulifolia VAHL的抗闭合性和抗炎活动。（Lamiaceae）精油和（ - ） - α-丙基洛尔，其主要化合物，小鼠
3. Evidence for the involvement of TNF-alpha and IL-1 beta in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-alpha-bisabolol, its main compound, in mice [J] . Barreto Rosana S. S., Quintans Jullyana S. S., Amarante Ruthy K. L., Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2016,第Null期

机译：TNF-α和IL-1β参与水苏草的抗伤害感受和抗炎活性的证据。（鼠尾草科）精油和（-）-α-bisabolol，其主要化合物，在小鼠中
4. Differential effects of lactacystin on IL-1 beta and TNF-alpha induced adhesion molecule expression and myeloid cell adhesion to endothelial cells [C] . Dagia, N.M., Goetz, . 2002

机译：乳胞素对IL-1β和TNF-α诱导的黏附分子表达和髓样细胞对内皮细胞黏附的影响
5. Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha IL-1 beta IL-10 by human leucocytes. [O] . A M van Furth, E M Verhard-Seijmonsbergen, R van Furth, 1997

机译：赖索茶碱和己酮可可碱对细菌刺激人白细胞产生TNF-αIL-1βIL-10的影响。
6. Evidence for a dual mechanism for IL-10 suppression of TNF-alpha production that does not involve inhibition of p38 mitogen-activated protein kinase or NF-kappa B in primary human macrophages. [O] . Denys, A, Udalova, IA, Smith, C, 2002

机译：IL-10抑制TNF-α产生的双重机制的证据，其中不涉及抑制人类原代巨噬细胞中p38丝裂原活化的蛋白激酶或NF-κB。

Evidence for the involvement of TNF-alpha, IL-1 beta and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents

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