Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway

Du Yumin; Chi Xiaowen; An Wen

首页> 外文期刊>Chemico-biological interactions >Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway

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Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway

机译：MicroRNA-200C-3P的下调通过上调Reck表达并灭活AKT信号通路，减少了癫痫大鼠海马神经元的损伤

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Objective: The aim of this study is to investigate the role of mircoRNA-200c-3p (miR-200c-3p) on hippocampal neuron injury in epileptic rats through the regulation of the AKT signaling pathway by targeting RECK.

机译：目的：本研究的目的是通过靶向RECK调节AKT信号通路的调节，探讨Mircorna-200c-3p（miR-200c-3p）对癫痫大鼠海马神经元损伤的作用。

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《Chemico-biological interactions》 |2019年第2019期|共11页
作者
Du Yumin; Chi Xiaowen; An Wen;
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作者单位

Harbin Med Univ Affiliated Hosp 1 Dept Pediat 30 Liaoyang St Harbin 150001 Heilongjiang;

Harbin Med Univ Affiliated Hosp 1 Dept Pediat 30 Liaoyang St Harbin 150001 Heilongjiang;

Harbin Med Univ Affiliated Hosp 1 Dept Pediat 30 Liaoyang St Harbin 150001 Heilongjiang;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
microRNA-200c-3p; Hippocampal neurons; Epilepsy; RECK; AKT signaling pathway;

机译：microRNA-200C-3P;海马神经元;癫痫;RECK;AKT信号通路;

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专利

1. Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway [J] . Du Yumin, Chi Xiaowen, An Wen Chemico-biological interactions . 2019,第期

机译：MicroRNA-200C-3P的下调通过上调Reck表达并灭活AKT信号通路，减少了癫痫大鼠海马神经元的损伤
2. Downregulation of lncRNA UCA1 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson's disease through the inhibition of the PI3K/Akt signaling pathway [J] . Cai Lijun, Tu Li, Li Tian, International immunopharmacology . 2019,第期

机译：LNCRNA UCA1的下调改善了多巴胺能神经元的损伤，通过抑制PI3K / AKT信号通路来减少帕金森病的氧化应激和炎症
3. The effect of IL-1 beta on synaptophysin expression and electrophysiology of hippocampal neurons through the PI3K/Akt/mTOR signaling pathway in a rat model of mesial temporal lobe epilepsy [J] . Xiao Zhaohua, Peng Jing, Wu Liwen, Neurological Research: An Interdisciplinary Quarterly Journal . 2017,第7期

机译：IL-1β对患有PI3K / AKT / MTOR信号传导途径在弱间隙脑癫痫大鼠模型中的Hippopampal神经元突起神经元的影响
4. Ganoderma Lucidum Reduces Kainic Acid-Induced Hippocampal Neuronal Damage via Inflammatory Cytokines and Glial Fibrillary Acid Protein Expression [C] . Aguirre Moreno A.C, Campos Pena V., Villeda Hernez J., Western Pharmacology Society . 2011

机译：灵芝通过炎症细胞因子和胶质纤维酸蛋白表达减少了Kinain酸诱导的海马神经元损伤
5. Role of the phosphatidylinositol (PI) 3-kinase/Akt protein kinase signaling pathway in the survival of rat sympathetic neurons [D] . Crowder, Robert J. 2000

机译：磷脂酰肌醇（PI）3-激酶/ Akt蛋白激酶信号通路在大鼠交感神经元存活中的作用
6. Losmapimod Protected Epileptic Rats From Hippocampal Neuron Damage Through Inhibition of the MAPK Pathway [O] . Min Li, Lexiang Cui, Xuemin Feng, -1

机译：Losmapimod通过抑制MAPK途径保护癫痫大鼠免受海马神经元损害
7. Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway [O] . Yinbao Qi, Ruobing Qian, Li Jia, 2020

机译：过度表达的MicroRNA-494通过灭活NF-κB信号通路来抑制RIPK1以抑制癫痫大鼠的海马神经元损伤

Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway

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