Ytterbium(III) Trifluoromethanesulfonate Catalyzed Ring-Opening C(sp(3))-N Bond Formation of Benzoxazoles with Propargylic Alcohols

摘要

A novel ytterbium(III) trifluoromethanesulfonate [Yb(OTf)(3)]-catalyzed ring-opening C(sp(3))-N bond formation reaction of benzoxazole with propargylic alcohols was established. This reaction uses readily available starting materials and is operationally simple; it thus represents a practical method for the construction of highly functionalized substituted benzenes bearing aldehyde, propargylamine, and hydroxy groups with high atom economy.