Stereoselective Synthesis of Borylated 1,3-Dienes by Synergistic Cu/Pd Catalysis

摘要

A Cu/Pd-catalyzed alkenylboration of alkynes with alkenyl bromides and bis(pinacolato)diboron is reported. This transformation features the generation of a catalytic beta-boryl-substituted C(sp(2))-Cu intermediate and subsequent Pd-catalyzed cross-coupling. The reaction tolerates a wide array of substrates and affords diversely substituted syn-borylated 1,3-dienes under mild conditions with total regio- and stereocontrol.