Catalytic Branching Cascades in Diversity Oriented Synthesis

摘要

Diversity oriented synthesis (DOS) aims to generate small mol-ecules with great structural diversity in an efficient manner. Recent years have witnessed significant achievements in the field, which help to validate the usefulness of DOS as a tool for the discovery of novel, biologically interesting small molecules. Catalytic branching cascades have emerged as a promising strategy because of their potential to transform a common type of substrate into diverse and distinct molecular frameworks. The details of the concept are presented herein.