The Highly Efficient Suzuki-Miyaura Cross-Coupling of (Hetero)aryl Chlorides and (Hetero)arylboronic Acids Catalyzed by 'Bulky-yet-Flexible' Palladium-PEPPSI Complexes in Air

摘要

A series of Pd-PEPPSI complexes were designed and synthesized. The relationship between catalyst structure and properties was systematically investigated. It was revealed that bulky-yet-flexible C3 bearing ancenaphthyl backbone was a highly efficient precatalyst and could be successfully employed in Suzuki-Miyaura reactions of (hetero)aryl chlorides with (hetero)arylboronic acids at a low palladium loading in the presence of a weak inorganic base in air.