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首页> 外文期刊>Chembiochem: A European journal of chemical biology >Discovery of Antimicrobial Lipodepsipeptides Produced by a SerratiaSerratia sp. within Mosquito Microbiomes
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Discovery of Antimicrobial Lipodepsipeptides Produced by a SerratiaSerratia sp. within Mosquito Microbiomes

机译：发现抗微生物脂质肽肽肽肽肽肽肽肽肽肽肽肽肽肽SP。 在蚊子微生物体内

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Abstract > The Anopheles mosquito that harbors the Plasmodium parasite contains a microbiota that can influence both the vector and the parasite. In recent years, insect‐associated microbes have highlighted the untapped potential of exploiting interspecies interactions to discover bioactive compounds. In this study, we report the discovery of nonribosomal lipodepsipeptides that are produced by a Serratia sp. within the midgut and salivary glands of Anopheles stephensi mosquitoes. The lipodepsipeptides, stephensiolides?A–K, have antibiotic activity and facilitate bacterial surface motility. Bioinformatic analyses indicate that the stephensiolides are ubiquitous in nature and are likely important for Serratia spp. colonization within mosquitoes, humans, and other ecological niches. Our results demonstrate the usefulness of probing insect–microbiome interactions, enhance our understanding of the chemical ecology within Anopheles mosquitoes, and provide a secondary‐metabolite scaffold for further investigate of this complex relationship. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> > anopheles </ i>蚊子，哈勃疟原虫</ i>寄生虫含有微生物，可以影响载体和寄生虫。近年来，昆虫相关的微生物突出了利用剥削梭菌相互作用以发现生物活性化合物的未开发的潜力。在这项研究中，我们报告了由Slatia Sp产生的非纤维素脂溢性肽的发现。在 anopheles stephensi </ i>蚊子的中肠和唾液腺内。 Lipodepsipeptips，Stephensiolides？A-K，具有抗生素活性并促进细菌表面活力。生物信息分析表明Stephensiolides本质上是普遍的，并且可能对 Serratia </ i> SPP很重要。蚊子，人类和其他生态利基内的殖民化。我们的结果表明了探测昆虫 - 微生物组合的有用性，增强了我们对蚊虫中的化学生态学的理解，并提供二次代谢支架以进一步研究这种复杂关系。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16039/'>《Chembiochem: A European journal of chemical biology》</a> <b style="margin: 0 2px;">|</b><span>2018年第15期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ganley Jack G.&option=202" target="_blank" rel="nofollow">Ganley Jack G.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carr Gavin&option=202" target="_blank" rel="nofollow">Carr Gavin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ioerger Thomas R.&option=202" target="_blank" rel="nofollow">Ioerger Thomas R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sacchettini James C.&option=202" target="_blank" rel="nofollow">Sacchettini James C.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Clardy Jon&option=202" target="_blank" rel="nofollow">Clardy Jon;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Derbyshire Emily R.&option=202" target="_blank" rel="nofollow">Derbyshire Emily R.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryDuke University124 Science Drive Durham NC 27708-0346 USA;</p> <p>Department of Biological Chemistry and Molecular PharmacologyHarvard Medical School240 Longwood Avenue Boston MA 02115 USA;</p> <p>Department of Computer ScienceTexas A&</p> <p>M UniversityCollege Station TX 77843 USA;</p> <p>Department of Biochemistry and BiophysicsTexas A&</p> <p>M UniversityCollege Station TX 77843 USA;</p> <p>Department of Biological Chemistry and Molecular PharmacologyHarvard Medical School240 Longwood Avenue Boston MA 02115 USA;</p> <p>Department of ChemistryDuke University124 Science Drive Durham NC 27708-0346 USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/179.html" title="分子生物学">分子生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=lipodepsipeptides&option=203" rel="nofollow">lipodepsipeptides;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microbiome&option=203" rel="nofollow">microbiome;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mosquitoes&option=203" rel="nofollow">mosquitoes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=natural products&option=203" rel="nofollow">natural products;</a> </p> <div class="translation"> 机译：Lipodepsipeptips;Microbiome;蚊子;天然产品; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022055800.html">Discovery of Antimicrobial Lipodepsipeptides Produced by a <i >SerratiaSerratia sp. within Mosquito Microbiomes</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ganley Jack G.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ganley Jack G.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carr Gavin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Carr Gavin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ioerger Thomas R.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ioerger Thomas R.,</a> <a href="/journal-foreign-16039/" target="_blank" rel="nofollow" class="tuijian_authcolor">Chembiochem: A European journal of chemical biology .</a> <span>2018</span><span>,第15期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：发现抗微生物脂质肽肽肽肽肽肽肽肽肽肽肽肽肽肽SP。 在蚊子微生物体内</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704019011929.html">Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kishimoto S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kishimoto S.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tsunematsu Y.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tsunematsu Y.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nishimura S.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Nishimura S.,</a> <a href="/journal-foreign-30440/" target="_blank" rel="nofollow" class="tuijian_authcolor">Tetrahedron .</a> <span>2012</span><span>,第27a28期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Tumescenamide C，一种来自链霉菌属的抗菌环脂二肽。</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_croatica-chemica-acta_thesis/02041506117.html">Cyclic Lipodepsipeptides in Novel Antimicrobial Drug Discovery</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nina Bionda&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Nina Bionda,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Predrag Cudic&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Predrag Cudic </a> <a href="/journal-foreign-5202/" target="_blank" rel="nofollow" class="tuijian_authcolor">Croatica Chemica Acta .</a> <span>2011</span><span>,第2期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：新型抗菌药物发现中的环脂肽</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-282242_thesis/0705013702495.html">Antimicrobial Protein Produced by Lactobacillus plantarum ATCC8014 in the Presence of Cymbopogon sp. 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<b>[P]</b> . <span> 外国专利： <!-- 韩国专利： --> KR101493800B1 </span> <span> . 2015-02-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Marine Bacillus sp。生产的具有抗菌活性的新化合物。 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130414275724.html">NOVEL COMPOUND HAVING ANTIMICROBIAL ACTIVITY PRODUCED BY MARINE BACILLUS SP. 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