Pre-operative cytodiagnosis of an adult granulosa cell tumour: Report of a case with its differential diagnosis

摘要

Dear Editor, Although the role of fine needle aspiration (FNA) cytology is still under debate, its application in the precise diagnosis and management of selective ovarian malignancies is well emphasized. Most studies on the cytology of ovarian tumours deal with surface epithelial and germ cell tumours, with only a limited literature available on sex-cord stromal tumours. Granulosa cell tumour (GCT) is the most common sex-cord stromal tumour accounting for less than 3% of all ovarian tumours. Clinically, an adult granulosa tumour (AGCT) is seen in postmenopausal women, whereas a juvenile granulosa tumour affects younger females. Although, his-tomorphology of GCT and its variants is well established, their cytodiagnosis can be challenging. Owing to the lack of a significant nuclear pleomor-phism, an AGCT is often misdiagnosed or overlooked on cytology.