The Association Between Alcohol Consumption and Renal Tubular Dysfunction Induced by Cadmium Exposure

摘要

Alcohol consumption is inversely associated with the risk of chronic kidney diseases. However, this association has not been reported in populations exposed to cadmium. In the present study, we examined the association between alcohol consumption and renal tubular dysfunction in populations living in cadmium-polluted areas. A total of 446 subjects (170 men and 276 women) were finally included in our analysis. The urinary cadmium (UCd) and cadmium in blood (BCd) were determined as the exposure biomarkers. Urinary N-acetyl-beta-d-glucosaminidase (UNAG) and beta(2)-microgloblin (UBMG) were measured as renal indicators. Alcohol drinking patterns were obtained from a questionnaire and divided into four categories: non-drinking, light drinking ( 7 drinks /week). If UNAG was the indicator of renal dysfunction, the prevalence of renal tubular dysfunction was decreased in subjects with alcohol consumption both in men (chi(2) = 8.5, p 3.0 mu g/L) or UCd (> 5.0 mu g/g creatinine). Our data show that alcohol consumption is inversely associated with cadmium-induced renal tubular dysfunction.