Modelling persistent        <fi >Mycoplasma pneumoniae</fi>Mycoplasma pneumoniae        infection of human airway epithelium

Prince Oliver A.; Krunkosky Thomas M.; Sheppard Edward S.; Krause Duncan C.

摘要

Abstract > <fi>Mycoplasma pneumoniae</fi> is a human respiratory tract pathogen causing acute and chronic airway disease states that can include long‐term carriage and extrapulmonary spread. The mechanisms of persistence and migration beyond the conducting airways, however, remain poorly understood. We previously described an acute exposure model using normal human bronchial epithelium (NHBE) in air–liquid interface culture, showing that <fi>M.?pneumoniae</fi> gliding motility is essential for initial colonisation and subsequent spread, including localisation to epithelial cell junctions. We extended those observations here, characterizing <fi>M.?pneumoniae</fi> infection of NHBE for up to 4?weeks. Colonisation of the apical surface was followed by pericellular invasion of the basolateral compartment and migration across the underlying transwell membrane. Despite fluctuations in transepithelial electrical resistance and increased NHBE cell desquamation, barrier function remained largely intact. Desquamation was accompanied by epithelial remodelling that included cytoskeletal reorganisation and development of deep furrows in the epithelium. Finally, <fi>M.?pneumoniae</fi> strains S1 and M129 differed with respect to invasion and histopathology, consistent with contrasting virulence in experimentally infected mice. In summary, this study reports pericellular invasion, NHBE cytoskeletal reorganisation, and tissue remodelling with persistent infection in a human airway epithelium model, providing clear insight into the likely route for extrapulmonary spread. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> > <fi> mycoplasma pneumoniae </ fi>是一种人类呼吸道病原体，导致急性和慢性气道疾病的状态可包括长期托架和外涂层蔓延。然而，超越导电气道的持久性和迁移的机制仍然明白很差。我们之前描述了使用空气液体界面培养中的正常人支气管上皮（NHBE）的急性曝光模型，表明<fi> m.?pneumoniae </ fi>滑动运动对于初始定植和随后的涂抹至关重要，包括上皮的定位细胞连接。我们在此扩展了这些观察结果，表征<fi> m.nknneumoniae </ fi> Nhbe的感染最多4个星期。顶部表面的定植，然后是基底间隔的脑外侵袭和穿过下面的Transwell膜的迁移。尽管在TRANSEPITHELIAL电阻和增加的NHBE细胞脱屑增加中，屏障功能仍然很完整。脱落伴随着上皮重塑，包括细胞骨骼重组和上皮中深沟的发育。最后，<fi> m.?pneumoniae </ fi>菌株S1和M129相对于侵袭和组织病理学不同，与实验感染的小鼠的对比毒力一致。总之，本研究报告了人类气道上皮模型中垂直侵袭，NHBE细胞骨骼重组和组织重组，并对肺外涂层的可能途径提供了清晰的洞察力。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共11页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Prince Oliver A.&option=202" target="_blank" rel="nofollow">Prince Oliver A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Krunkosky Thomas M.&option=202" target="_blank" rel="nofollow">Krunkosky Thomas M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sheppard Edward S.&option=202" target="_blank" rel="nofollow">Sheppard Edward S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Krause Duncan C.&option=202" target="_blank" rel="nofollow">Krause Duncan C.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of MicrobiologyUniversity of GeorgiaAthens GA USA;</p> <p>Department of Veterinary Biosciences and Diagnostic ImagingUniversity of GeorgiaAthens GA USA;</p> <p>Department of MicrobiologyUniversity of GeorgiaAthens GA USA;</p> <p>Department of MicrobiologyUniversity of GeorgiaAthens GA USA;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Airway epithelium&option=203" rel="nofollow">Airway epithelium;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=in vitro modelling&option=203" rel="nofollow">in vitro modelling;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mycoplasma pneumoniae&option=203" rel="nofollow">Mycoplasma pneumoniae;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=persistent infection&option=203" rel="nofollow">persistent infection;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=respiratory disease&option=203" rel="nofollow">respiratory disease;</a> </p> <div class="translation"> 机译：气道上皮;体外造型;支原体肺炎;持续感染;呼吸系统疾病; 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中国奶业协会第24次繁殖学术年会暨国家奶牛/肉牛产业技术体系第一届全国牛病防治学术研讨会 </a> <span> <span> . 2009</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020316088015.html">徐州地区住院儿童肺炎支原体呼吸道感染的流行病学及肺炎支原体肺炎的临床特征分析</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘怀彬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘怀彬</a> <span> . 2020</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120112785289.html">基于影像组学的鉴别实性小儿肺炎支原体肺炎与肺炎链球菌肺炎的方法和系统</a> <b>[P]</b> . <span> 中国专利： CN112807008A </span> <span> . 2021-05-18</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/061204790070.html">用于制备羊支原体肺炎疫苗的组合菌株、羊支原体肺炎三价灭活疫苗及其制备方法</a> <b>[P]</b> . <span> 中国专利： CN111690554B </span> <span> . 2021.11.23</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130500686424.html">PRIMER SETS FOR DETECTION OF MYCOPLASMA PNEUMONIAE BACTERIA, METHOD FOR DETECTION OF MYCOPLASMA PNEUMOANIAE INFECTION, USE OF A PRIMER SET FOR DETECTION OF MYCOPLASMA PNEUMONIAE INFECTION</a> <b>[P]</b> . <span> 外国专利：  WO2021187994A1 </span> <span> . 2021-09-23</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于检测支原体肺炎细菌的引物套，检测支原体肺炎感染的方法，使用引物底座检测支原体肺炎肺炎感染 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130429136214.html">Use of mycoplasma protein 8C2 to assay biological samples for antibodies produced as a result of Mycoplasma pneumoniae infections</a> <b>[P]</b> . <span> 外国专利：  FR2922648A1 </span> <span> . 2009-04-24</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: 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Modelling persistent Mycoplasma pneumoniaeMycoplasma pneumoniae infection of human airway epithelium

摘要