Discordant susceptibility of inbred C57BL/6 versus outbred CD1 mice to experimental fungal sepsis

Carreras Esther; Velasco de Andrés María; Orta‐Mascaró Marc; Sim?es Inês T.; Català Cristina; Zaragoza Oscar; Lozano Francisco

摘要

Abstract > Individual susceptibility differences to fungal infection following invasive and/or immunosuppressive medical interventions are an important clinical issue. In order to explore immune response‐related factors that may be linked to fungal infection susceptibility, we have compared the response of inbred C57BL/6J and outbred CD1 mouse strains to different experimental models of fungal sepsis. The challenge of animals with the zymosan‐induced generalised inflammation model revealed poorer survival rates in C57BL/6J, consistent with lower Th1 cytokine interferon (IFN)‐γ serum levels, compared with CD1 mice. Likewise, ex vivo exposure of C57BL/6J splenocytes to zymosan but also bacterial lipopolisaccharide or lipoteichoic acid, resulted in lower IFN‐γ secretion compared with CD1 mice. C57BL/6J susceptibility could be reverted by rescue infusion of relative low IFN‐γ doses (0.2?μg/kg) either alone or in combination with the ? ‐glucan‐binding CD5 protein (0.7?mg/kg) leading to improved post zymosan‐induced generalised inflammation survival. Similarly, low survival rates to systemic <fc> <fi>Candida albicans</fi> </fc> infection (2.86?×?10 4 ?CFU/gr) were ameliorated by low‐dose IFN‐γ infusion in C57BL/6J but not CD1 mice. Our results highlight the importance of strain choice in experimental fungal infection models and provide a susceptibility rationale for more specific antifungal immunotherapy designs. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> >侵入性和/或免疫抑制医疗干预措施后对真菌感染的个体易感性差异是重要的临床问题。为了探索可能与真菌感染易感性相关的免疫应答相关因素，比较了近交C57BL / 6J和差异CD1小鼠菌株对真菌败血症的不同实验模型的响应。与酵母诱导的广义炎症模型的动物挑战揭示了C57BL / 6J中的较差的存活率，与CD1小鼠相比，与下Th1细胞因子干扰素（IFN）-γ血清水平一致。同样， exvivo </ i>将C57BL / 6J脾细胞暴露于唑苯虫，而且还导致细菌脂多糖或脂肪异酸，导致较低的IFN-γ分泌与CD1小鼠相比。可以通过单独或与结合的相对低IFN-γ剂量（0.2×μg/ kg）拯救输注相对低IFN-γ剂量（0.2×μg/ kg）或与β-结合的CD5蛋白（0.7Ω·mg / kg）导致改善酵母诱导的广义炎症存活后。类似地，对系统性的低生存率<FC> <FI> Candida albicans </ Fi> </ Fc>感染（2.86？×10 4 </ sup>Δcfu/ gr）被低剂量IFN改善-γ输注在C57BL / 6J中但不是CD1小鼠。我们的结果突出了实验性真菌感染模型中应变选择的重要性，并为更具体的抗真菌免疫治疗设计提供了易感性理由。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15891/'>《Cellular microbiology》</a> <b style="margin: 0 2px;">|</b><span>2019年第5期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Carreras Esther&option=202" target="_blank" rel="nofollow">Carreras Esther;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Velasco de Andrés María&option=202" target="_blank" rel="nofollow">Velasco de Andrés María;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Orta‐Mascaró Marc&option=202" target="_blank" rel="nofollow">Orta‐Mascaró Marc;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sim?es Inês T.&option=202" target="_blank" rel="nofollow">Sim?es Inês T.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Català Cristina&option=202" target="_blank" rel="nofollow">Català Cristina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zaragoza Oscar&option=202" target="_blank" rel="nofollow">Zaragoza Oscar;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lozano Francisco&option=202" target="_blank" rel="nofollow">Lozano Francisco;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Immunoreceptors of the Innate and Adaptive System teamInstitut d'Investigacions Biomèdiques August Pi i SunyerBarcelona Spain;</p> <p>Immunoreceptors of the Innate and Adaptive System teamInstitut d'Investigacions Biomèdiques August Pi i SunyerBarcelona Spain;</p> <p>Immunoreceptors of the Innate and Adaptive System teamInstitut d'Investigacions Biomèdiques August Pi i SunyerBarcelona Spain;</p> <p>Immunoreceptors of the Innate and Adaptive System teamInstitut d'Investigacions Biomèdiques August Pi i SunyerBarcelona Spain;</p> <p>Immunoreceptors of the Innate and Adaptive System teamInstitut d'Investigacions Biomèdiques August Pi i SunyerBarcelona Spain;</p> <p>Mycology Reference LaboratoryNational Centre for Microbiology Instituto de Salud Carlos III MajadahondaMadrid Spain;</p> <p>Immunoreceptors of the Innate and Adaptive System teamInstitut d'Investigacions Biomèdiques August Pi i SunyerBarcelona Spain;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/173.html" title="普通生物学">普通生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=C57BL/6J mice&option=203" rel="nofollow">C57BL/6J mice;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Candida albicans&option=203" rel="nofollow">Candida albicans;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=CD1 mice&option=203" rel="nofollow">CD1 mice;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=fungal sepsis&option=203" rel="nofollow">fungal sepsis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=IFN‐γ&option=203" rel="nofollow">IFN‐γ;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=zymosan&option=203" rel="nofollow">zymosan;</a> </p> <div class="translation"> 机译：C57BL / 6J小鼠;Candida albicans;CD1小鼠;真菌败血症;IFN-γ;Zymosan; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704022031868.html">Discordant susceptibility of inbred C57BL/6 versus outbred CD1 mice to experimental fungal sepsis</a> <b>[J]</b> . <span> <a 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Wen&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">John H. Wen,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Laura Miyares&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Laura Miyares,</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：差异CD1小鼠与执行社会任务的近交C57BL / 6J小鼠一样合适</span> </p> </li> <li> <div> <b>8. </b><a class="enjiyixqcontent" href="/ntis-science-report_de_thesis/020711788397.html">EPIDERMAL CARCINOGENICITY OF BIS [2,3-EPOXYCYCLOPENTYL] ETHER, 2,2-BIS (p-GLYCIDYLOXYPHENYL)PROPANE, AND m-PHENYLENEDIAMINE IN C3H AND C57BL/6 INBRED MALE AND FEMALE MICE</a> <b>[R] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=J. M. Holland&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">J. M. 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Gipson </a> <span>1978</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：BIs [2,3-EpOXYCYCLOpENTYL]醚，2,2-BIs（对 - 羟基氧基苯基）丙烷和m-苯二胺在C3H和C57BL / 6母鼠和雌性小鼠中的表皮致癌性</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_shaanxi-journal-traditional-chinese-medicine_thesis/0201270390116.html">三参生血颗粒对60Co照射所致C57BL/6小鼠造血及免疫系统不良反应治疗作用的研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘文秀&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘文秀</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨娟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,杨娟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=曹博&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,曹博</a> <span> <a href="/journal-cn-5673/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 陕西中医 </a> </span> <span> . 2019</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_world-chinese-medicine_thesis/0201217908454.html">C57BL/6J小鼠实验性自身免疫性脑脊髓炎模型建立的关键性问题</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=吴彦青&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 吴彦青</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=郭玉红&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,郭玉红</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘清泉&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘清泉</a> <span> <a href="/journal-cn-5678/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界中医药 </a> </span> <span> . 2017</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_henan-medical-research_thesis/0201248060166.html">实验性自身免疫性脑脊髓炎（EAE）C57BL/6J 小鼠模型构建</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄夏冰&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 黄夏冰</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=康巧珍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,康巧珍</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王晓东&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王晓东</a> <span> <a href="/journal-cn-6611/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 河南医学研究 </a> </span> <span> . 2015</span><span>,第008期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-immunology_thesis/0201223372533.html">SOCS1-JAK2-STAT3信号通路在C57BL/6小鼠实验性自身免疫性脑脊髓炎模型中作用机制探讨</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=董梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 董梅</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=辛立建&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,辛立建</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈丽萍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,陈丽萍</a> <span> <a href="/journal-cn-5793/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国免疫学杂志 </a> </span> <span> . 2014</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_shaanxi-medical-journal_thesis/0201250051188.html">人腺病毒Ⅲ型致C57BL小鼠实验性腺病毒肺炎实验研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=楚建平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 楚建平</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张国成&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张国成</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=许东亮&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,许东亮</a> <span> <a href="/journal-cn-6650/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 陕西医学杂志 </a> </span> <span> . 2009</span><span>,第004期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-43204_thesis/020222767397.html">C57BL/6小鼠实验性变态反应性脑脊髓炎模型的建立</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LIAN Gao-jian&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . LIAN Gao-jian</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=练高建&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,练高建</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=YANG Shen-shu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,YANG Shen-shu</a> <span> <a href="/conference-cn-43204/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第十七届中南地区实验动物科技交流会 </a> <span> <span> . 2017</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314363058.html">电针调节功能性消化不良C57BL小鼠SCF/c-kit信号通路的实验研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=程泓&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 程泓</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204928830.html">血液净化装置及其控制方法以及脱血不良消除方法</a> <b>[P]</b> . <span> 中国专利： CN110461389B </span> <span> . 2022.02.25</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120101480954.html">血液净化装置及其控制方法以及脱血不良消除方法</a> <b>[P]</b> . <span> 中国专利： CN110461389A </span> <span> . 2019-11-15</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130419200993.html">METHOD TO TREAT EXPERIMENTAL TUBERCULOSIS IN MICE OF LINE C57BL/6(H-2<Sup>b</Sup>)</a> <b>[P]</b> . <span> 外国专利：  RU2496868C1 </span> <span> . 2013-10-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：C57BL / 6（H-2 <Sup> b </ Sup>）系小鼠实验性结核病的治疗方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul 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