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Critical role of TNF inhibition in combination therapy for elderly mice with atherosclerosis

机译:TNF抑制在随动脉粥样硬化的老年小鼠组合治疗中的关键作用

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AimsWe have previously shown that the combination of pravastatin and sarpogrelate is synergistically beneficial for atherosclerosis. In this study, we investigated whether the pravastatin-sarpogrelate combination was sufficient for treatment in an old mouse model of atherosclerosis or if additional intervention would be needed to address the newly included aging factor and its complex pathophysiological impact on the atherosclerogenic state. We added an anti-TNF biological to the combination treatment cocktail because of the known pathologic roles of TNF in the aging process.
机译:AIMSWE先前表明,普伐他汀和莎培生素的组合对于动脉粥样硬化是协同的有益。 在这项研究中,我们研究了普伐他汀-Sarpogelelate组合是否足以在动脉粥样硬化的旧小鼠模型中治疗,或者如果需要额外的干预以解决新包括的老化因子及其对动脉粥样硬化状态的复杂病理生理学影响。 由于TNF在老化过程中的已知病理作用,我们将抗TNF生物学添加到联合治疗鸡尾酒中。

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