Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese

Tanabe Yuko; Shimizu Chikako; Hamada Akinobu; Hashimoto Kenji; Ikeda Kazutaka; Nishizawa Daisuke; Hasegawa Junko; Shimomura Akihiko; Ozaki Yukinori; Tamura Nobuko; Yamamoto Harukaze; Yunokawa Mayu; Yonemori Kan; Takano Toshimi; Kawabata Hidetaka; Tamura Kenji; Fujiwara Yasuhiro

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Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese

机译：紫杉醇诱导的感觉外周神经病变与ABCB1单核苷酸多态性和日本老年人有关

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Purpose Whether age and inter-individual variability of pharmacogenetics are risk factors for paclitaxel-induced peripheral neuropathy (PIPN) is inconclusive. This study was conducted to evaluate the influence of previously investigated single nucleotide polymorphisms (SNPs) and age, using genotype data from a prospective study of paclitaxel-related toxicity in Japanese patients with breast cancer.

机译：目的是药物原因的年龄和单独的各种变异性是紫杉醇诱导的周围神经病变（PIPN）的危险因素是不确定的。进行该研究以评估先前研究的单核苷酸多态性（SNP）和年龄的影响，使用基因型数据来自日本乳腺癌紫杉醇相关毒性的前瞻性研究。

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来源
《Cancer chemotherapy and pharmacology.》 |2017年第6期|共8页
作者
Tanabe Yuko; Shimizu Chikako; Hamada Akinobu; Hashimoto Kenji; Ikeda Kazutaka; Nishizawa Daisuke; Hasegawa Junko; Shimomura Akihiko; Ozaki Yukinori; Tamura Nobuko; Yamamoto Harukaze; Yunokawa Mayu; Yonemori Kan; Takano Toshimi; Kawabata Hidetaka; Tamura Kenji; Fujiwara Yasuhiro;
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作者单位

Natl Canc Ctr Dept Expt Therapeut Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

Natl Canc Ctr Dept Breast &

Med Oncol Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

Kumamoto Univ Grad Sch Med Sci Dept Med Oncol &

Translat Res Chuo Ku 1-1-1 Honjyo Kumamoto;

Natl Canc Ctr Dept Breast &

Med Oncol Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

Tokyo Metropolitan Inst Med Sci Addict Subst Project Setagaya Ku 2-1-6 Kamikitazawa Tokyo;

Tokyo Metropolitan Inst Med Sci Addict Subst Project Setagaya Ku 2-1-6 Kamikitazawa Tokyo;

Tokyo Metropolitan Inst Med Sci Addict Subst Project Setagaya Ku 2-1-6 Kamikitazawa Tokyo;

Natl Canc Ctr Dept Breast &

Med Oncol Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

Toranomon Gen Hosp Dept Med Oncol Minato Ku 2-2-2 Toranomon Tokyo 1058470 Japan;

Toranomon Gen Hosp Dept Breast &

Endocrine Surg Minato Ku 2-2-2 Toranomon Tokyo 1058470 Japan;

Natl Canc Ctr Dept Breast &

Med Oncol Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

Natl Canc Ctr Dept Breast &

Med Oncol Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

Natl Canc Ctr Dept Breast &

Med Oncol Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

Toranomon Gen Hosp Dept Med Oncol Minato Ku 2-2-2 Toranomon Tokyo 1058470 Japan;

Toranomon Gen Hosp Dept Breast &

Endocrine Surg Minato Ku 2-2-2 Toranomon Tokyo 1058470 Japan;

Natl Canc Ctr Dept Expt Therapeut Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

Natl Canc Ctr Dept Breast &

Med Oncol Chuo Ku 5-1-1 Tsukiji Tokyo 1040045 Japan;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Paclitaxel-induced peripheral neuropathy; Older age; SLCO1B3; CYP2C8; ABCB1;

机译：紫杉醇诱导的周围神经病变;老年人;SLCO1B3;CYP2C8;ABCB1;

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专利

1. Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese [J] . Tanabe Yuko, Shimizu Chikako, Hamada Akinobu, Cancer chemotherapy and pharmacology. . 2017,第6期

机译：紫杉醇诱导的感觉外周神经病变与ABCB1单核苷酸多态性和日本老年人有关
2. Identification of novel single nucleotide polymorphisms located in MAP3K1 and ABCB1 genes as markers for poor overall survival in early-stage hormone receptor-positive breast cancer using next-generation sequencing [J] . Intelligence: A Multidisciplinary Journal . 2020,第期

机译：鉴定位于MAP3K1和ABCB1基因的新型单核苷酸多态性，作为使用下一代测序的早期激素受体阳性乳腺癌整体存活差的标志物
3. Frequencies and roles of CYP3A5, CYP3A4 and ABCB1 single nucleotide polymorphisms in Italian teenagers after kidney transplantation. [J] . Turolo S, Tirelli AS, Ferraresso M, Pharmacological reports: PR . 2010,第6期

机译：CYP3A5，CYP3A4和ABCB1单核苷酸多态性在意大利青少年肾脏移植后的频率和作用。
4. Tumor Necrosis Factor-alpha (TNF-alpha) Gene -238 Single Nucleotide Polymorphism (SNP) Is Associated with Low TNF-a Production from Peripheral Blood Mononuclear Cells (PBMCs) in Japanese [C] . K. Shuno, M. Aoyama, S. Fudo, Conference on Shock . 2008

机译：肿瘤坏死因子-α（TNF-α）基因-238单核苷酸多态性（SNP）与日本外周血单核细胞（PBMC）的低TNF-A生产相关
5. A Gene-environment Study of Metallothionein Single Nucleotide Polymorphisms, Mercury Biomarker Levels and Peripheral Nerve Function. [D] . Wang, Yi. 2011

机译：金属硫蛋白单核苷酸多态性，汞生物标志物水平和周围神经功能的基因环境研究。
6. Taxane-induced sensory peripheral neuropathy is associated with an SCN9A single nucleotide polymorphism in Japanese patients [O] . Yuko Tanabe, Seiji Shiraishi, Kenji Hashimoto, 2020

机译：紫杉烷诱导的感觉周围神经病与日本患者的SCN9A单核苷酸多态性相关
7. Association of Single Nucleotide Polymorphisms in STAT3, ABCB1, and ABCG2 with Stomatitis in Patients with Metastatic Renal Cell Carcinoma Treated with Sunitinib: A Retrospective Analysis in Japanese Patients [O] . Aimi Watanabe, Kazuhiro Yamamoto, Takeshi Ioroi, 2017

机译：单核苷酸多态性在 Stat3， ABCB1，和 ABCG2和 ABCG2 - 患者中，用Sunitinib治疗的转移性肾细胞癌的患者进行了口腔炎：回顾性分析日本患者

Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese

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