Circulating long non-coding RNA MALAT1 expression as molecular biomarker in Egyptian patients with breast cancer

摘要

Highlights ? MALAT1 expression was significantly elevated in breast cancer. ? Sensitivity and specificity were 83.7% and 81.2% for MALAT1 expression. ? Sensitivity and specificity were 77.5% and 82.5% for CA15-3 expression. ? MALAT1 expression possesses a prognostic value of breast cancer. The abnormal contribution of long non-coding RNA (lncRNAs) expression to human tumorigenesis is still a matter of debate. Breast cancer is the most common cancer in females; it represents a terrible problem in our country. The aim of this research was to assess the role of MALAT1, as one of lncRNAs, as a potential biomarker in breast cancer. This study comprised 80 patients with breast cancer and 80 controls. MALAT1 expression was measured by RT-quantitative polymerase chain reaction (qPCR). CA15-3 was estimated using chemiluminescence immunoassay (CLIA). MALAT1 expression was significantly elevated in breast cancer cases compared to controls (P?