Dexmedetomidine pharmacokineticpharmacodynamic modelling in healthy volunteers: 1. Influence of arousal on bispectral index and sedation

摘要

Background. Dexmedetomidine, a selective alpha(2)-adrenoreceptor agonist, has unique characteristics, such as maintained respiratory drive and production of arousable sedation. We describe development of a pharmacokinetic-pharmacodynamic model of the sedative properties of dexmedetomidine, taking into account the effect of stimulation on its sedative properties.