Construction of Near-infrared Irradiation-controlled Drug Delivery System Based on Silica @polypyrrole@mesoporous Silica and PEG-PCL-PEG

摘要

Cancer is one of the world's most serious concerns and it has more than 10 million new cases every year.1 Current cancer treatments include radiation and chemotherapy, which can rapidly kill the dividing cells in the body. However, conventional chemotherapeutic agents encounter such a problem that they cannot be delivered selectively to the cancer cells, thus damaging the surrounding healthy cells. Therefore, the development of smart and biocompatible drug delivery systems for the sustained delivery of drugs is of significant importance in biomedicine and pharmaceutics. The past years have witnessed the development and applications of hydrogels in biomedical fields because of their non-toxicity, high water retention, weak interactions with cellular and molecular components, and excellent biocompatibility.3 Particularly, stimuli-sensitive hydrogels have sparked great interest in drug delivery applications owing to the reversible gel-sol transition behavior responding to the external stimuli including light,4 pH,5 temperature,6 and so on. Although stimuli-sensitive hydrogels have been widely studied and achieved significant processes in recent years, the development of hydrogels-based functional composite materials for stimuli-responsive drug delivery is still urgently needed for biomedicine and pharmaceutics.