An Amide Analog of (-)-Epigallocatechin Gallate Shows Preferential Cytotoxicity toward Triple-Negative Breast Cancer Cells

摘要

MDA-MB-231 is a highly aggressive, invasive and poorly differentiated triple-negative breast cancer (TNBC) cell line as it lacks estrogen receptor and progesterone receptor expression, as well as HER2 (human epidermal growth factor receptor 2) amplification.1,2 Similar to other invasive cancers, there are only limited treatment options for TNBC and, as a result, there is an urgent need to discover cytotoxic agents against the MDA-MB-231 cells.