Bortezomib-induced peripheral neuropathy is related to altered levels of brain-derived neurotrophic factor in the peripheral blood of patients with multiple myeloma

摘要

Loss of nerve growth factor-mediated neuronal survival has recently been proposed as a candidate mechanism underlying bortezomib-induced peripheral neuropathy (BIPN) (Broyl et al, 2010). However the literature does not reveal any data from patients that can support this hypothesis. Brain-derived neurotrophic factor (BDNF) is a neuronal growth factor that is crucial for neuronal survival and repair (Hofer & Barde, 1988). We report on alterations in BDNF peripheral blood levels and the development of BIPN in patients with multiple myeloma (MM).