Delta Np63 activates EGFR signaling to induce loss of adhesion in triple-negative basal-like breast cancer cells

摘要

The basal-A subtype of triple-negative breast cancer is characterized by high levels of Delta Np63. Various functions have been proposed for p63 in breast cancer initiation and growth, and p63 mediates chemotherapeutic response in a subset of triple-negative breast cancers. We investigated the signaling pathways that are controlled by Delta Np63 in basal-A triple-negative breast cancer.