SRF-YAP YAP New molecular diagnosis/therapy of triple basal-like breast cancer and negative breast cancers using SRF-YAP and YAP signature

摘要

The present invention relates to a novel biomarker for diagnosis and treatment of basal-like breast cancer (BLBC) or triple negative breast cancer characterized by SRF-YAP over-expressing tumor stem cells, and a composition and method for diagnosing and treating such diseases More specifically, MASC-YAP signature genes associated with SRF-YAP that can induce mammary stem cells can be identified and mRNA of these genes or the expression level of the mRNAs of these genes can be measured. Basal-like The present invention provides an effective diagnosis of breast cancer showing features of SRF-YAP overexpressing genetic tumor stem cells among breast cancer, BLBC, and triple negative breast cancer, and further provides a method for inhibiting activation of MASC-YAP signature transcription factor SRF-YAP overexpressing genetic tumors by administration of a binding substance. Triple negative breast cancer and basal cell carcinoma showing stem cell characteristics. A pharmaceutical composition and a screening method capable of drastically improving a therapeutic efficacy.