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Prediction of functionally significant single nucleotide polymorphisms in PTENPTEN tumor suppressor gene: An in silicoin silico approach

机译：在 pten Pten肿瘤抑制基因：A // WWW中的功能显着的单核苷酸多态性预测 wiley.com/namespaces/wiley"inein silico 在硅的方法中

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Abstract > The phosphatase and tensin homolog ( PTEN ) gene plays a crucial role in signal transduction by negatively regulating the PI3K signaling pathway. It is the most frequent mutated gene in many human‐related cancers. Considering its critical role, a functional analysis of missense mutations of PTEN gene was undertaken in this study. Thirty five nonsynonymous single nucleotide polymorphisms (nsSNPs) within the coding region of the PTEN gene were selected for our in silico investigation, and five nsSNPs (G129E, C124R, D252G, H61D, and R130G) were found to be deleterious based on combinatorial predictions of different computational tools. Moreover, molecular dynamics (MD) simulation was performed to investigate the conformational variation between native and all the five mutant PTEN proteins having predicted deleterious nsSNPs. The results of MD simulation of all mutant models illustrated variation in structural attributes such as root‐mean‐square deviation, root‐mean‐square fluctuation, radius of gyration, and total energy; which depicts the structural stability of PTEN protein. Furthermore, mutant PTEN protein structures also showed a significant variation in the solvent accessible surface area and hydrogen bond frequencies from the native PTEN structure. In conclusion, results of this study have established the deleterious effect of the all the five predicted nsSNPs on the PTEN protein structure. Thus, results of the current study can pave a new platform to sort out nsSNPs that can be undertaken for the confirmation of their phenotype and their correlation with diseased status in case of control studies. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> >磷酸酶并且Tensin Homolog（ Pten </ i>）基因通过对PI3K信号通路负极调节PI3K信号传导途径在信号转导中起着至关重要的作用。它是许多人类相关癌症中最常见的突变基因。考虑到其关键作用，在本研究中进行了对 PTEN </ i>基因的畸形突变的功能分析。在Silico Chersigation中选择35个非纯单核苷酸多态性（NSSNP）在硅中的在Silico Chization中，以及五个NSSNPS（G129E，C124R，D252G，H61D基于不同计算工具的组合预测，发现和R130G被发现是有害的。此外，进行分子动力学（MD）模拟以研究天然和所有五个突变体之间的构象变化 PTEN蛋白，其具有预测的有害NSSNPS的蛋白质。所有突变模型的MD模拟结果显示了结构属性的变化，如根均方偏差，根均方波动，环状半径和总能量;描绘了 Pten </ i>蛋白的结构稳定性。此外，突变体 PTEN </ i>蛋白质结构还显示出溶剂可接近表面积和来自天然 PTEN的结构的显着变化。总之，本研究的结果已经建立了所有五个预测的NSSNPS对 Pten </ i>蛋白质结构的有害效果。因此，目前研究的结果可以铺平新平台，以解决可以进行的NSSNP，以确认其表型及其与对照研究的患病状态的相关性。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15016/'>《Biotechnology and Applied Biochemistry》</a> <b style="margin: 0 2px;">|</b><span>2017年第5期</span><b style="margin: 0 2px;">|</b><span>共10页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Khan Imran&option=202" target="_blank" rel="nofollow">Khan Imran;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ansari Irfan A.&option=202" target="_blank" rel="nofollow">Ansari Irfan A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Singh Pratichi&option=202" target="_blank" rel="nofollow">Singh Pratichi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dass J Febin Prabhu&option=202" target="_blank" rel="nofollow">Dass J Febin Prabhu;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of BiosciencesIntegral UniversityLucknow India;</p> <p>Department of BiosciencesIntegral UniversityLucknow India;</p> <p>School of Biosciences and TechnologyVellore Institute of TechnologyVellore Tamilnadu India;</p> <p>School of Biosciences and TechnologyVellore Institute of TechnologyVellore Tamilnadu India;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a><a href="https://www.zhangqiaokeyan.com/clc/177.html" title="生物化学">生物化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=deleterious&option=203" rel="nofollow">deleterious;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=in silico&option=203" rel="nofollow">in silico;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=PTEN&option=203" rel="nofollow">PTEN;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=RMSD&option=203" rel="nofollow">RMSD;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=signaling pathways&option=203" rel="nofollow">signaling pathways;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SNP&option=203" rel="nofollow">SNP;</a> </p> <div class="translation"> 机译：有害;在硅;PTEN;RMSD;信号通路;SNP; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704021881108.html">Prediction of functionally significant single nucleotide polymorphisms in <i xmlns="http://www.wiley.com/namespaces/wiley">PTENPTEN tumor suppressor gene: An <i xmlns="http://www.wiley.com/namespaces/wiley">in silicoin silico approach</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Khan Imran&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Khan Imran,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ansari Irfan A.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ansari Irfan A.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Singh Pratichi&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Singh Pratichi,</a> <a href="/journal-foreign-15016/" target="_blank" rel="nofollow" class="tuijian_authcolor">Biotechnology and Applied Biochemistry .</a> <span>2017</span><span>,第5期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：在<i XMLNS =“http://www.wiley.com/namespaces/wiley”> pten </ i> Pten肿瘤抑制基因：A // WWW中的功能显着的单核苷酸多态性预测 wiley.com/namespaces/wiley"inein silico </ i>在硅的方法中</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704020203649.html">Prediction of Large Enhancement of Electron Mobility in Direct Gap Ge <sub xmlns="http://www.wiley.com/namespaces/wiley"> 1? x </sub> 1? <i xmlns="http://www.wiley.com/namespaces/wiley">xx Sn <sub xmlns="http://www.wiley.com/namespaces/wiley"> x </sub> <i xmlns="http://www.wiley.com/namespaces/wiley">xx Alloy</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mukhopadhyay Bratati&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mukhopadhyay Bratati,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sen Gopa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Sen Gopa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Basu Rikmantra&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Basu Rikmantra,</a> <a href="/journal-foreign-29289/" target="_blank" rel="nofollow" class="tuijian_authcolor">Physica status solidi, B. 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Jrbo A.</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kaino T.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Kaino T.</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Arnes M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Arnes M.</a> <span> <a href="/journal-cn-6197/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 世界核心医学期刊文摘：妇产科学分册 </a> </span> <span> . 2005</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-clinical-experimental-pathology_thesis/0201241239772.html">肿瘤抑制基因PTEN/MMAC1/TEP1在肿瘤研究中的进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=彭惠&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 彭惠</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=杨光华&option=202" target="_blank" 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