首页> 外文期刊>Biotechnology and Applied Biochemistry >Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells

【24h】

Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells

机译：吉西他滨通过胰腺癌细胞中的AMPK / MTOR信号通路诱导细胞凋亡和自噬

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Abstract > Gemcitabine (GEM)‐based chemotherapy is a commonly used treatment for pancreatic cancer. However, acquired drug resistance, a major problem in pancreatic cancer treatment, causes a reduction in the survival rate of patients with cancer. In this study, we attempted to reveal the molecular mechanism of GEM resistance. Our data showed that GEM treatment inhibits cell growth, induces apoptosis, and activates autophagy via the AMP‐activated protein kinase (AMPK) pathway. The combination of GEM treatment and AMPK knockdown resulted in a dramatic increase of apoptosis and inhibition of autophagy. Additionally, inhibition of mammalian target of Rapamycin induced autophagy. Our findings show the potential therapeutic implications of the combined treatment with GEM and AMPK inhibitors for pancreatic cancer. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> > gemcitabine（基础的化疗是胰腺癌的常用治疗方法。然而，获得的耐药性是胰腺癌治疗中的一个主要问题，导致癌症患者的存活率降低。在这项研究中，我们试图揭示宝石抗性的分子机制。我们的数据显示，GEM治疗抑制细胞生长，诱导细胞凋亡，并通过AMP活化的蛋白激酶（AMPK）途径激活自噬。宝石治疗和安培的组合导致凋亡和抑制自噬的显着增加。另外，抑制哺乳动物催乳素诱导的自噬靶。我们的研究结果表明，与胰腺癌的GEM和AMPK抑制剂的潜在治疗潜在的治疗意义。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15016/'>《Biotechnology and Applied Biochemistry》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhu Jinhui&option=202" target="_blank" rel="nofollow">Zhu Jinhui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Yan&option=202" target="_blank" rel="nofollow">Chen Yan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ji Yun&option=202" target="_blank" rel="nofollow">Ji Yun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yu Yuanquan&option=202" target="_blank" rel="nofollow">Yu Yuanquan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jin Yun&option=202" target="_blank" rel="nofollow">Jin Yun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Xiaoxiao&option=202" target="_blank" rel="nofollow">Zhang Xiaoxiao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhou Jiale&option=202" target="_blank" rel="nofollow">Zhou Jiale;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of General Surgery and Laparoscopic CenterSecond Affiliated Hospital Zhejiang University School of MedicineHangzhou People's Republic of China;</p> <p>Department of General Surgery and Laparoscopic CenterSecond Affiliated Hospital Zhejiang University School of MedicineHangzhou People's Republic of China;</p> <p>Department of General SurgerySecond Affiliated Hospital Zhejiang University School of MedicineHangzhou People's Republic of China;</p> <p>Department of General SurgerySecond Affiliated Hospital Zhejiang University School of MedicineHangzhou People's Republic of China;</p> <p>Department of General SurgerySecond Affiliated Hospital Zhejiang University School of MedicineHangzhou People's Republic of China;</p> <p>Department of General SurgerySecond Affiliated Hospital Zhejiang University School of MedicineHangzhou People's Republic of China;</p> <p>Department of General SurgerySecond Affiliated Hospital Zhejiang University School of MedicineHangzhou People's Republic of China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a><a href="https://www.zhangqiaokeyan.com/clc/177.html" title="生物化学">生物化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=AMPK&option=203" rel="nofollow">AMPK;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=apoptosis&option=203" rel="nofollow">apoptosis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=autophagy&option=203" rel="nofollow">autophagy;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=gemcitabine&option=203" rel="nofollow">gemcitabine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pancreatic cancer&option=203" rel="nofollow">pancreatic cancer;</a> </p> <div class="translation"> 机译：AMPK;细胞凋亡;自噬;吉西他滨;胰腺癌; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704021881023.html">Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhu Jinhui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Zhu Jinhui,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chen Yan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chen Yan,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ji Yun&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ji Yun,</a> <a href="/journal-foreign-15016/" target="_blank" rel="nofollow" class="tuijian_authcolor">Biotechnology and Applied Biochemistry .</a> <span>2018</span><span>,第5期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：吉西他滨通过胰腺癌细胞中的AMPK / MTOR信号通路诱导细胞凋亡和自噬</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204122024961.html">Oleanolic Acid Induces Autophagy and Apoptosis via the AMPK-mTOR Signaling Pathway in Colon Cancer</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Changxiao Hu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Changxiao Hu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yibo Cao&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Yibo Cao,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ping Li&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ping Li,</a> <a href="/journal-foreign-35309/" target="_blank" rel="nofollow" class="tuijian_authcolor">Journal of oncology .</a> <span>2021</span><span>,第a期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：OleAlic acid通过结肠癌中的AMPK-MTOR信号传导途径诱导自噬和细胞凋亡</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023722012.html">Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic beta-cell death through modulation of autophagy via AMPK/mTOR signaling pathway</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Varshney Ritu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Varshney Ritu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gupta Sumeet&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gupta Sumeet,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Roy Partha&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Roy Partha </a> <a href="/journal-foreign-25197/" target="_blank" rel="nofollow" class="tuijian_authcolor">Molecular and Cellular Endocrinology .</a> <span>2017</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Kaempferol对棕榈酸诱导的胰腺β细胞死亡通过AMPK / MTOR信号传导途径的调节方法的细胞保护作用</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-199245_thesis/020513637776.html">Cationic polystyrene nanosphere induces autophagy through inhibition of the Akt/mTOR and activation of the AMPK signaling pathways in macrophage and epithelial cells</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hui-Wen Chiu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hui-Wen Chiu,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tian Xia&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tian Xia,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jui-Chen Tsai&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Jui-Chen Tsai,</a> <a href="/conference-foreign-199245/" target="_blank" rel="nofollow" class="tuijian_authcolor">Annual NSTI nanotechnology conference and expo .</a> <span>2013</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：阳离子聚苯乙烯纳米球通过抑制Akt / mTOR和激活巨噬细胞和上皮细胞中的AMPK信号通路来诱导自噬</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061132240.html">Integration ofmTOR and IGF-1 signaling: Feedback upregulation of survival pathways in human cancer cells.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=O'Reilly, Kathryn Elizabeth.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">O'Reilly, Kathryn Elizabeth. </a> <span>2007</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：mTOR和IGF-1信号传导的整合：人癌细胞中生存途径的反馈上调。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/040006589996.html">Isoquercitrin induces apoptosis and autophagy in hepatocellular carcinoma cells via AMPK/mTOR/p70S6K signaling pathway</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liyan Shui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Liyan Shui,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Weina Wang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Weina Wang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mingjie Xie&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Mingjie Xie,</a> <span>2020</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：isoquercitrin通过AMPK / MTOR / P70S6K信号通路诱导肝细胞癌细胞中的细胞凋亡和自噬</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/01000129802234.html">Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chao-Hsiang Chang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chao-Hsiang Chang,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chao-Ying Lee&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chao-Ying Lee,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Chi-Cheng Lu&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Chi-Cheng Lu,</a> <span>2017</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：白藜芦醇诱导的顺铂抗性人口腔癌电池细胞的自噬和凋亡：AMPK和AKT / MTOR信号传导的关键作用</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-gastroenterology-hepatology_thesis/0201276014693.html">DPC4基因通过mTOR信号通路诱导胰腺癌细胞自噬</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邵丽春&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邵丽春</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓国伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邓国伟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=卞晓丽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,卞晓丽</a> <span> <a href="/journal-cn-15009/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 胃肠病学和肝病学杂志 </a> </span> <span> . 2019</span><span>,第012期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-journal-pathophysiology_thesis/0201272930291.html">紫草素通过PI3K/Akt/mTOR信号通路诱导人宫颈癌HeLa细胞凋亡和自噬</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=WANG Shu-hui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . WANG Shu-hui</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=YIN Xiu-yan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,YIN Xiu-yan</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LIU Hai-ying&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,LIU Hai-ying</a> <span> <a href="/journal-cn-5784/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国病理生理杂志 </a> </span> <span> . 2019</span><span>,第007期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-pharmacological-bulletin_thesis/0201291829969.html">补阳还五汤通过AMPK/mTOR/ULK1信号通路调控自噬减轻大鼠脑缺血/再灌注损伤</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=马秀娟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 马秀娟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵艳萌&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵艳萌</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王文良&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王文良</a> <span> <a href="/journal-cn-6427/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国药理学通报 </a> </span> <span> . 2022</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_practical-journal-cardiac-cerebral-pneumal-vascular-disease_thesis/0201272571542.html">不同剂量阿托伐他汀对急性脑缺血/再灌注损伤大鼠血管内皮功能的影响及其与自噬相关信号通路Ca2+/AMPK/mTOR的关系研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李玉竹&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 李玉竹</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邹梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,邹梅</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=于周&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,于周</a> <span> <a href="/journal-cn-5978/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 实用心脑肺血管病杂志 </a> </span> <span> . 2019</span><span>,第005期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_medical-pharmaceutical-journal-chinese-people-liberation-army_thesis/0201273534483.html">褪黑素通过AMPK-mTOR信号通路介导的自噬在神经元缺血缺氧损伤中的作用研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=陈继军&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 陈继军</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王倩梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,王倩梅</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵鹏&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵鹏</a> <span> <a href="/journal-cn-17340/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 解放军医药杂志 </a> </span> <span> . 2019</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-5989_thesis/020221526248.html">白藜芦醇通过抑制Akt/mTOR/p70S6k-4EBP-1及激活p38-MAPK信号路径诱导急性T淋巴细胞白血病细胞凋亡及自噬</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=葛娇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 葛娇</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李强</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘燕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘燕</a> <span> <a href="/conference-cn-5989/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中华医学会第十八次全国儿科学术会议 </a> <span> <span> . 2013</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020315282378.html">西格列汀对高糖诱导下人脐静脉内皮细胞自噬及AMPK/mTOR信号通路的影响</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王鑫&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王鑫</a> <span> . 2019</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061204749545.html">桔梗多糖通过自噬在拮抗伏马毒素B1诱导的细胞凋亡中的用途</a> <b>[P]</b> . <span> 中国专利： CN111358805B </span> <span> . 2021.11.02</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120103842614.html">桔梗多糖通过自噬在拮抗伏马毒素B1诱导的细胞凋亡中的用途</a> <b>[P]</b> . <span> 中国专利： CN111358805A </span> <span> . 2020-07-03</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130422102008.html">ISOOCTYLPHENOL DERIVATIVE INDUCING THE APOPTOSIS OF CANCER CELLS BY IMPROVING THE ACTIVITY OF AMPK, AND A USE THEREOF AS AN ANTI-CANCER DRUG</a> <b>[P]</b> . <span> 外国专利：  KR101099895B1 </span> <span> . 2011-12-28</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：异辛酚衍生物可通过改善ampk的活性来诱导癌细胞的凋亡，并将其用作抗癌药物 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130422998249.html">mTOR inhibtors and mTOR signaling pathway inhibitors induce differentiation of human embryonic stem cells into the osteoblastic lineage</a> <b>[P]</b> . <span> 外国专利：  US8093050B2 </span> <span> . 2012-01-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：mTOR抑制剂和mTOR信号通路抑制剂可诱导人类胚胎干细胞分化为成骨细胞系 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130500235910.html">METHOD OF INDUCING AND STIMULATING PANCREATIC CANCER STEM CELLS AND CANCER CELLS TO APOPTOSIS</a> <b>[P]</b> . <span> 外国专利：  WO2021137840A1 </span> <span> . 2021-07-08</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：诱导和刺激胰腺癌干细胞和癌细胞对细胞凋亡的方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704021881023','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche">  </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);">回到顶部</a> </li> <li class="shouye"> <a href="/">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html">关于掌桥</a></li> <li><a href="/help/helpmap.html">资源导航</a></li> <li><a href="/help/helpguide.html">新手指南</a></li> <li><a href="/help/helpcenter.html">常见问题</a></li> <li><a href="/sitemap.html">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704021881023down" data-source="7," data-out-id="6QBs2PXFcfzKcxWYOTELa3Mjf1BHYKSXLTGJoln2KLCsyuDa50guSjG+GgpGlF9m," data-f-source-id="7" data-title="Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="15016" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.7"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.7"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>