In vitro cytotoxic activity of microalgal extracts loaded nano–micro particles produced via electrospraying and microemulsion methods

Karaka? Canan Y.; Tekarslan ?ahin Hande; ?nan Benan; ?z?imen Didem; Erginer Y?ld?z ?.

摘要

Abstract > Reactive oxygen species can bind protein, DNA, lipids, and carbohydrates and thus cause an oxidation reaction that induces various syndromes such as cardiovascular diseases, degenerative disease, and cancer types in the human body. Bioactive compounds, such as PUFA, EPA, DHA, and carotenoids in algae, have a chain ring and protect the tissue from chemical damage and reverse the symptoms of some diseases. Algal bioactives also have various biological properties such as anticoagulants, antiviral, antiangiogenic, antitumor, anti‐inflammatory, antioxidant, antiproliferative, and immune modulation properties. This study aimed to show in vitro cytotoxic activity effect of Chlorella protothecoides and Nannochloropsis oculata microalgal extracts loaded nano–microparticles on A‐172 ( Homo sapiens brain glioblastoma) and HCT‐116 ( H. sapiens colon colorectal carcinoma) cell lines because of the increasing importance of algal biotechnology. MTT viability tests were performed on HUVEC, A172, and HCT 116 cells with particles obtained at optimum process parameters. The cell viability rates of encapsulated particles were also compared with pure algae extracts. Microalgal extracts loaded nano–micro particles showed very promising results for cytotoxic effect on cancer cells. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> > 活性氧物质可以结合蛋白质，DNA，脂质和碳水化合物，从而引起氧化反应，诱导人体中的各种综合征，退行性疾病和癌症类型。生物活性化合物，如Pufa，EPA，DHA和藻类类胡萝卜素，具有链环并保护组织免受化学损伤，并逆转一些疾病的症状。藻类生物术也具有各种生物学性质，例如抗凝血剂，抗病毒，抗血管生成，抗肿瘤，抗炎，抗氧化剂，抗增殖和免疫调节性能。本研究旨在显示体外细胞毒性活性效果小摄氏性原子骨（Chorthella protcheates）</ i> 和 nannchloropsis oculata </ i> 微藻提取物在A-172上加载纳米微粒（ homo sapiens </ i> 脑胶质母细胞瘤）和HCT-116（ h。 sapiens </ i> 结肠结肠直肠癌）细胞系，因为藻类生物技术的重要性越来越重要。在Huvec，A172和HCT116细胞上对MTT活力测试进行，其中颗粒在最佳过程参数下获得。将包封颗粒的细胞活力率与纯藻类提取物进行比较。微藻提取物负载纳米微颗粒显示出对癌细胞对细胞毒性作用的有前途的结果。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15005/'>《Biotechnology Progress》</a> <b style="margin: 0 2px;">|</b><span>2019年第6期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Karaka? Canan Y.&option=202" target="_blank" rel="nofollow">Karaka? Canan Y.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tekarslan ?ahin Hande&option=202" target="_blank" rel="nofollow">Tekarslan ?ahin Hande;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=?nan Benan&option=202" target="_blank" rel="nofollow">?nan Benan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=?z?imen Didem&option=202" target="_blank" rel="nofollow">?z?imen Didem;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Erginer Y?ld?z ?.&option=202" target="_blank" rel="nofollow">Erginer Y?ld?z ?.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Faculty of Chemical and Metallurgical Engineering Food Engineering DepartmentY?ld?z Technical UniversityIstanbul Turkey;</p> <p>Faculty of Pharmacy Department of Pharmaceutical TechnologyIstanbul UniversityIstanbul Turkey;</p> <p>Faculty of Chemical and Metallurgical Engineering Bioengineering DepartmentY?ld?z Technical UniversityIstanbul Turkey;</p> <p>Faculty of Chemical and Metallurgical Engineering Bioengineering DepartmentY?ld?z Technical UniversityIstanbul Turkey;</p> <p>Faculty of Pharmacy Department of Pharmaceutical TechnologyIstanbul UniversityIstanbul Turkey;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/15.html" title="生物科学">生物科学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anticancer effect&option=203" rel="nofollow">anticancer effect;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=electrospraying&option=203" rel="nofollow">electrospraying;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microalgae&option=203" rel="nofollow">microalgae;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=microemulsion&option=203" rel="nofollow">microemulsion;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nanotechnology&option=203" rel="nofollow">nanotechnology;</a> </p> <div class="translation"> 机译：抗癌效果;电喷雾;微藻;微乳液;纳米技术; </div> </li> </ul> </div> </div> <div class="literature cardcommon" id="literaturereference" style="display:none"> <div class="similarity "> <h3 class="all_title" id="enpatent111">引文网络</h3> <div class="referencetab clearfix"> <ul id="referencedaohang"> <li dataid="referenceul">参考文献</li> <li dataid="citationul">引证文献</li> <li dataid="commonreferenceul">共引文献</li> <li dataid="commoncitationul">同被引文献</li> <li dataid="tworeferenceul">二级参考文献</li> <li dataid="twocitationul">二级引证文献</li> </ul> </div> <div class="reference_details" id="referenceList"> <ul id="referenceul"></ul> <ul id="citationul"></ul> <ul id="commonreferenceul"></ul> <ul id="commoncitationul"></ul> <ul id="tworeferenceul"></ul> <ul id="twocitationul"></ul> </div> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704021880160.html">In vitro cytotoxic activity of microalgal extracts loaded nano–micro particles produced via electrospraying and microemulsion methods</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Karaka? 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