A fully chimeric IgG antibody for ROR1 suppresses ovarian cancer growth in vitro and in vivo

Yin Zhengna; Mao Yuan; Zhang Ningzhi; Su Yiping; Zhu Jin; Tong Hua; Zhang Huilin

首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >A fully chimeric IgG antibody for ROR1 suppresses ovarian cancer growth in vitro and in vivo

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A fully chimeric IgG antibody for ROR1 suppresses ovarian cancer growth in vitro and in vivo

机译：用于ROR1的完全嵌合IgG抗体在体外和体内抑制卵巢癌生长

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Background: Over-expression of Receptor-tyrosine-kinase-like Orphan Receptor 1 (ROR1) in cancer cells has been reported in the context of several tumors (including ovarian cancer) and is associated with poor prognosis. The aim of this study was to construct a fully chimeric anti-ROR1 IgG antibody (ROR1-IgG) and investigate its antitumor activity against ovarian cancer cells, bothin vitro and in vivo.

机译：背景：在几种肿瘤（包括卵巢癌）的情况下，癌细胞中受体 - 酪氨酸激酶样孤儿状孤儿1（ROR1）的过表达据报道，并且与预后不良有关。该研究的目的是构建完全嵌合的抗ROR1 IgG抗体（ROR1-IgG），并研究其对卵巢癌细胞，体外和体内的抗肿瘤活性。

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来源
《Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie 》 |2019年第119期| 共10页
作者
Yin Zhengna; Mao Yuan; Zhang Ningzhi; Su Yiping; Zhu Jin; Tong Hua; Zhang Huilin;
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作者单位

Fuyang Peoples Hosp Dept Obstet &

Gynecol Fuyang 236000 Peoples R China;

Nanjing Med Univ Jiangsu Prov Geriatr Hosp Geriatr Hosp Dept Hematol &

Oncol Nanjing 210000;

Fuyang Peoples Hosp Dept Obstet &

Gynecol Fuyang 236000 Peoples R China;

Nanjing Med Univ Womens Hosp Dept Obstet &

Gynecol Nanjing Matern &

Child Hlth Care Hosp 123;

Huadong Med Inst Biotech Nanjing 210002 Jiangsu Peoples R China;

Nanjing Med Univ Womens Hosp Dept Obstet &

Gynecol Nanjing Matern &

Child Hlth Care Hosp 123;

Nanjing Med Univ Womens Hosp Dept Obstet &

Gynecol Nanjing Matern &

Child Hlth Care Hosp 123;

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原文格式 PDF
正文语种 eng
中图分类治疗学 ;
关键词
ROR1; Monoclonal antibody; Ovarian cancer; Immunotherapy;

机译：ROR1;单克隆抗体;卵巢癌;免疫疗法;

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专利

1. A fully chimeric IgG antibody for ROR1 suppresses ovarian cancer growth in vitro and in vivo [J] . Yin Zhengna, Mao Yuan, Zhang Ningzhi, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2019 ,第119期

机译：用于ROR1的完全嵌合IgG抗体在体外和体内抑制卵巢癌生长
2. MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo [J] . Zhang Liyu, Li Zhihong, Gai Fengchun, Molecular medicine reports . 2015 ,第2aPta2期

机译：MicroRNA-137在体外和体内抑制上皮性卵巢癌中的肿瘤生长
3. MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo [J] . Zhang Liyu, Li Zhihong, Gai Fengchun, Molecular medicine reports . 2015 ,第2aPta1期

机译：MicroRNA-137在体外和体内抑制上皮性卵巢癌中的肿瘤生长
4. In Vitro Metal-Reactivity Is Associated With In Vivo Metal-Specific Antibodies (IgG) In Individuals with Metal Implants [C] . Marco Caieedo, Shelly Anderson, Anand Ready, Society for Biomaterials Transaction Annual Meeting vol.29 pt.2 . 2006

机译：金属植入物中个体的体外金属反应性与体内金属特异性抗体（IgG）相关
5. Characterization of Anti-Ricin Monoclonal Antibodies and the Construction of a Chimeric Murine-Human IgG2/K Anti-Ricin Monoclonal Antibody [D] . Vendramelli, Robert Matthew 2011

机译：抗蓖麻毒蛋白单克隆抗体的表征和鼠/人IgG2 / K嵌合抗蓖麻毒蛋白单克隆抗体的构建
6. A murine–human chimeric IgG antibody against vascular endothelial growth factor receptor 2 inhibits angiogenesis in vitro [O] . Guipeng Ding, Ximin Chen, Jin Zhu, 2014

机译：鼠抗人类血管内皮生长因子受体2的嵌合IgG抗体在体外抑制血管新生
7. MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo [O] . LIYU ZHANG, ZHIHONG LI, FENGCHUN GAI, 2015

机译：MicroRNA-137在体外和体内抑制上皮性卵巢癌中的肿瘤生长

A fully chimeric IgG antibody for ROR1 suppresses ovarian cancer growth in vitro and in vivo

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